11. Mitochondria: The Ultimate Tumor Suppressor

  1. Thomas N. Seyfried

Published Online: 29 MAY 2012

DOI: 10.1002/9781118310311.ch11

Cancer as a Metabolic Disease: On the Origin, Management and Prevention of Cancer

Cancer as a Metabolic Disease: On the Origin, Management and Prevention of Cancer

How to Cite

Seyfried, T. N. (2012) Mitochondria: The Ultimate Tumor Suppressor, in Cancer as a Metabolic Disease: On the Origin, Management and Prevention of Cancer, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118310311.ch11

Publication History

  1. Published Online: 29 MAY 2012
  2. Published Print: 8 JUN 2012

ISBN Information

Print ISBN: 9780470584927

Online ISBN: 9781118310311

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Keywords:

  • mitochondria, the ultimate tumor suppressor, gleaned from experimental data;
  • genome instability and mitochondrial dysfunction through RTG signaling;
  • normal mitochondria and malignant suppression, evidences in support;
  • from rho0 cells, normal mitochondria and in vivo tumorigenesis suppression;
  • normal mitochondria and Warburg reversal, when by insufficient respiration

Summary

This chapter contains sections titled:

  • Mitochondrial Suppression of Tumorigenicity

  • Normal Mitochondria Suppress Tumorigenesis in Cybrids

  • Evidence from rho0 Cells

  • Normal Mitochondria Suppress Tumorigenesis In Vivo

  • Normal Mouse Cytoplasm Suppresses Tumorigenic Phenotypes

  • Enhanced Differentiation and Suppressed Tumorigenicity in the Liver Microenvironment

  • Summary of Nuclear-Cytoplasmic Transfer Experiments

  • References