13. Metastasis

  1. Thomas N. Seyfried

Published Online: 29 MAY 2012

DOI: 10.1002/9781118310311.ch13

Cancer as a Metabolic Disease: On the Origin, Management and Prevention of Cancer

Cancer as a Metabolic Disease: On the Origin, Management and Prevention of Cancer

How to Cite

Seyfried, T. N. (2012) Metastasis, in Cancer as a Metabolic Disease: On the Origin, Management and Prevention of Cancer, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118310311.ch13

Publication History

  1. Published Online: 29 MAY 2012
  2. Published Print: 8 JUN 2012

ISBN Information

Print ISBN: 9780470584927

Online ISBN: 9781118310311

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Keywords:

  • metastasis, cellular origin of metastasis, sequential;
  • EMT of tumor metastasis, MET, a reexpression of epithelial features;
  • myeloid hypothesis, metastatic, from myeloid, hematopoietic stem cells;
  • TAM, macrophage metastasis and phagocytosis;
  • fusion hybrids with dysfunctional mitochondria, and damaged respiration

Summary

This chapter contains sections titled:

  • Metastasis Overview

  • Cellular Origin of Metastasis

  • Macrophages and Metastasis

  • Carcinoma of Unknown Primary Origin

  • Many Metastatic Cancers Express Multiple Macrophage Properties

  • Linking Metastasis to Mitochondrial Dysfunction

  • Revisiting the “Seed and Soil” Hypothesis of Metastasis

  • Revisiting the Mesenchymal Epithelial Transition (MET)

  • Genetic Heterogeneity in Cancer Metastases

  • Transmissible Metastatic Cancers

  • The Absence of Metastases in Crown-Gall Plant Tumors

  • Chapter Summary

  • References