17. Metabolic Management of Cancer

  1. Thomas N. Seyfried

Published Online: 29 MAY 2012

DOI: 10.1002/9781118310311.ch17

Cancer as a Metabolic Disease: On the Origin, Management and Prevention of Cancer

Cancer as a Metabolic Disease: On the Origin, Management and Prevention of Cancer

How to Cite

Seyfried, T. N. (2012) Metabolic Management of Cancer, in Cancer as a Metabolic Disease: On the Origin, Management and Prevention of Cancer, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118310311.ch17

Publication History

  1. Published Online: 29 MAY 2012
  2. Published Print: 8 JUN 2012

ISBN Information

Print ISBN: 9780470584927

Online ISBN: 9781118310311



  • cancer management in humans, using MET instead of the term DER;
  • rational strategies, therapies targeting tumor cell energy metabolism;
  • DER and tumor apoptosis, inconsistent with tumor cells as resistant to apoptosis;
  • DER and proapoptotic effects, from reduced glycolytic energy;
  • effective DER in tumor reduction, also to target glucose metabolism


This chapter contains sections titled:

  • Is it Dietary Content or Dietary Composition that Primarily Reduces Tumor Growth?

  • Dietary Energy Reduction and Therapeutic Fasting in Rodents and Humans

  • Ketogenic Diets

  • Glucagon and Insulin

  • Basal Metabolic Rate

  • Ketones and Glucose

  • Metabolic Management of Brain Cancer Using the KD

  • Glucose Accelerates Tumor Growth!

  • Glucose Regulates Blood Levels of Insulin and Insulin-Like Growth Factor 1

  • Dietary Energy Reduction is Antiangiogenic

  • Dietary Energy Reduction Targets Abnormal Tumor Vessels

  • Dietary Energy Reduction is Proapoptotic

  • Dietary Energy Reduction is Anti-Inflammatory

  • Targeting Energy Metabolism in Advanced Cancer

  • Differential Response of Normal Cells and Tumor Cells to Energy Stress

  • Dietary Energy Reduction is Anti-Invasive in Experimental Glioblastoma

  • Influence of Growth Site and Host on Tumor Progression

  • Implications of Dietary Energy Reduction for Anticancer Therapeutics

  • Targeting Glucose

  • Metformin

  • Synergistic Interaction of the Restricted Ketogenic Diet (KD-R) and 2-Deoxyglucose (2-DG)

  • Can Synergy Occur with the KD-R and Hyperbaric Oxygen Therapy?

  • Targeting Glutamine

  • Glutamine Targeting Inhibits Systemic Metastasis

  • Targeting Phagocytosis

  • Targeting the Microenvironment

  • Dietary Energy Reduction as a Mitochondrial Enhancement Therapy (MET)

  • Summary

  • References