8. Is Mitochondrial Glutamine Fermentation a Missing Link in the Metabolic Theory of Cancer?

  1. Thomas N. Seyfried

Published Online: 29 MAY 2012

DOI: 10.1002/9781118310311.ch8

Cancer as a Metabolic Disease: On the Origin, Management and Prevention of Cancer

Cancer as a Metabolic Disease: On the Origin, Management and Prevention of Cancer

How to Cite

Seyfried, T. N. (2012) Is Mitochondrial Glutamine Fermentation a Missing Link in the Metabolic Theory of Cancer?, in Cancer as a Metabolic Disease: On the Origin, Management and Prevention of Cancer, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118310311.ch8

Publication History

  1. Published Online: 29 MAY 2012
  2. Published Print: 8 JUN 2012

ISBN Information

Print ISBN: 9780470584927

Online ISBN: 9781118310311

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Keywords:

  • mitochondrial glutamine, whether a missing link in metabolic theory;
  • amino acid fermentation in mitochondria, energy through phosphorylation;
  • fermentation energy pathways, and cancer cell growth in hypoxic condition;
  • gene theory of cancer, defects, causing aerobic glycolysis and metabolic defects;
  • cancer cells and insufficient respiration, energy through fermentation

Summary

This chapter contains sections titled:

  • Amino Acid Fermentation can Maintain Cellular Energy Homeostasis During Anoxia

  • Evidence Suggesting that Metastatic Mouse Cells Derive Energy from Glutamine Fermentation

  • Fermentation Energy Pathways can Drive Cancer Cell Viability Under Hypoxia

  • Competing Explanations for the Metabolic Origin of Cancer

  • Chapter Summary

  • References