10. Management of Fulminant Hepatic Failure

  1. E. Jenny Heathcote MB, BS, MD, FRCP, FRCP(C)2,3,4,5
  1. Leslie B. Lilly MD, MSc, FRCPC1,3

Published Online: 4 SEP 2012

DOI: 10.1002/9781118314968.ch10

Hepatology: Diagnosis and Clinical Management

Hepatology: Diagnosis and Clinical Management

How to Cite

Lilly, L. B. (2012) Management of Fulminant Hepatic Failure, in Hepatology: Diagnosis and Clinical Management (ed E. J. Heathcote), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118314968.ch10

Editor Information

  1. 2

    Francis Family Chair in Hepatology Research, Toronto, Ontario, Canada

  2. 3

    University of Toronto, Toronto, Ontario, Canada

  3. 4

    Patient Based Clinical Research Division, Toronto Western Research Institute, Toronto, Ontario, Canada

  4. 5

    University Health Network/Toronto Western Hospital, Toronto, Ontario, Canada

Author Information

  1. 1

    Multi Organ Transplant Program, Toronto General Hospital, University Health Network, Toronto, Ontario, Canada

  2. 3

    University of Toronto, Toronto, Ontario, Canada

Publication History

  1. Published Online: 4 SEP 2012
  2. Published Print: 12 OCT 2012

ISBN Information

Print ISBN: 9780470656174

Online ISBN: 9781118314968

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Keywords:

  • fulminant;
  • hepatitis;
  • coma;
  • liver transplantation

Summary

Fulminant hepatic failure, a syndrome characterized by multiorgan dysfunction precipitated by acute liver injury in the absence of pre-existing liver disease, represents a unique management challenge. Efforts should be directed to three main goals: (1) identification of the precipitating cause, both to permit the use of disease-specific treatments and to aid in the estimation of prognosis and the appropriateness and timing of transplantation; (2) institution of supportive and prophylactic care measures, usually in the intensive care setting; and (3) determination of the timing of referral for emergency liver transplantation.