21. Vascular Diseases of the Liver

  1. E. Jenny Heathcote MB, BS, MD, FRCP, FRCP(C)2,3,4,5
  1. Jordan J. Feld MD, MPH1,3

Published Online: 4 SEP 2012

DOI: 10.1002/9781118314968.ch21

Hepatology: Diagnosis and Clinical Management

Hepatology: Diagnosis and Clinical Management

How to Cite

Feld, J. J. (2012) Vascular Diseases of the Liver, in Hepatology: Diagnosis and Clinical Management (ed E. J. Heathcote), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118314968.ch21

Editor Information

  1. 2

    Francis Family Chair in Hepatology Research, Toronto, Ontario, Canada

  2. 3

    University of Toronto, Toronto, Ontario, Canada

  3. 4

    Patient Based Clinical Research Division, Toronto Western Research Institute, Toronto, Ontario, Canada

  4. 5

    University Health Network/Toronto Western Hospital, Toronto, Ontario, Canada

Author Information

  1. 1

    Liver Centre, Division of Gastroenterology, Toronto Western Hospital, University Health Network, Toronto, Ontario, Canada

  2. 3

    University of Toronto, Toronto, Ontario, Canada

Publication History

  1. Published Online: 4 SEP 2012
  2. Published Print: 12 OCT 2012

ISBN Information

Print ISBN: 9780470656174

Online ISBN: 9781118314968

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Keywords:

  • portal vein thrombosis;
  • Budd–Chiari syndrome;
  • sinusoidal obstruction syndrome;
  • JAK2

Summary

A number of vascular problems can affect the liver. Portal vein thrombosis is the most common vascular disorder. The prognosis and management differs based on the presence or absence of cirrhosis. Thrombosis of the hepatic veins, Budd–Chiarisyndrome, is usually associated with a hypercoaguable condition and is an emergency in the acute setting. Sinusoidal obstruction syndrome occurs in the setting of cytotoxic chemotherapy and has a very poor prognosis; however, with better recognition of risk factors, the incidence has declined. The natural history, prognosis, and management of portal and hepatic vein thrombosis as well as sinusoidal obstruction syndrome are discussed.