25. Preventing GI Cancer in those at Risk

  1. C. J. Hawkey FMedSci5,
  2. Jaime Bosch MD, PhD6,7,
  3. Joel E. Richter MD, FACP, MACG8,9,
  4. Guadalupe Garcia-Tsao MD10,11 and
  5. Francis K. L. Chan MD12
  1. Nicola E. Burch MBChB, MRCP (UK) (Gastro), MSc (Hons)1 and
  2. Janusz A. Jankowski MD, PhD, FRCP, FACG2,3,4

Published Online: 16 APR 2012

DOI: 10.1002/9781118321386.ch25

Textbook of Clinical Gastroenterology and Hepatology, Second Edition

Textbook of Clinical Gastroenterology and Hepatology, Second Edition

How to Cite

Burch, N. E. and Jankowski, J. A. (2012) Preventing GI Cancer in those at Risk, in Textbook of Clinical Gastroenterology and Hepatology, Second Edition (eds C. J. Hawkey, J. Bosch, J. E. Richter, G. Garcia-Tsao and F. K. L. Chan), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118321386.ch25

Editor Information

  1. 5

    Nottingham Digestive Diseases Centre, University of Nottingham and Nottingham University Hospitals, Nottingham, UK

  2. 6

    Hepatic Hemodynamic Laboratory, Liver Unit Hospital Clínic-IDIBAPS, University of Barcelona, Spain

  3. 7

    Biomedical Research Centre Network of Hepatic and Digestive Diseases (CIBERehd), National Institute of Health Carlos III Ministry of Science and Innovation Barcelona, Spain

  4. 8

    Division of Gastroenterology and Nutrition, University of South Florida Tampa, FL, USA

  5. 9

    Joy M. Culverhouse Center for Esophageal Diseases, University of South Florida Tampa, FL, USA

  6. 10

    Section of Digestive Diseases Yale University, School of Medicine New Haven, CT, USA

  7. 11

    Veterans Affairs Connecticut Healthcare System West Haven, CT, USA

  8. 12

    Department of Medicine & Therapeutics The Chinese University of Hong Kong, Hong Kong SAR, China

Author Information

  1. 1

    University Hospitals Coventry and Warwickshire NHS Trust, Coventry, UK

  2. 2

    Digestive Diseases Centre UHL Trust, Leicester, London, UK

  3. 3

    University of Oxford, Oxford, London, UK

  4. 4

    Cancer Research UK and Queen Mary, University of London, London, UK

Publication History

  1. Published Online: 16 APR 2012
  2. Published Print: 20 APR 2012

ISBN Information

Print ISBN: 9781405191821

Online ISBN: 9781118321386



  • Chemoprevention;
  • Cancer prevention;
  • Barrett's esophagus;
  • Targeted endotherapy;
  • Targeted screening;
  • Colorectal cancer;
  • Surveillance


With GI cancer incidence increasing despite current surveillance and management strategies, it is vital that more emphasis be placed on cancer prevention strategies in those particularly at risk. Although not an exhaustive list this chapter will discuss the main at-risk groups for upper GI cancers including Barrett's esophagus, reflux esophagitis, H. pylori, gastric polyps, pernicious anemia and celiac disease, and lower GI cancers including colonic polyps and inflammatory bowel disease. Cancer risk of these groups will be discussed alongside the key points regarding disease-specific cancer prevention strategies. The latest research will be summarized with respect to exciting new endoscopic techniques which may revolutionize current surveillance protocols, and possible chemoprevention strategies will be evaluated. Practical key learning points are included which aim to be of benefit to trainees in gastroenterology.