3.1. Sulfonamide Antibacterial Agents

  1. Rosaleen J. Anderson1,
  2. Paul W. Groundwater2,
  3. Adam Todd1 and
  4. Alan J. Worsley3

Published Online: 29 MAY 2012

DOI: 10.1002/9781118325421.ch5

Antibacterial Agents: Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications

Antibacterial Agents: Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications

How to Cite

Anderson, R. J., Groundwater, P. W., Todd, A. and Worsley, A. J. (2012) Sulfonamide Antibacterial Agents, in Antibacterial Agents: Chemistry, Mode of Action, Mechanisms of Resistance and Clinical Applications, John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781118325421.ch5

Author Information

  1. 1

    Sunderland Pharmacy School, University of Sunderland, UK

  2. 2

    Faculty of Pharmacy, University of Sydney, Australia

  3. 3

    Department of Pharmacology and Pharmacy, The University of Hong Kong, Hong Kong SAR

Publication History

  1. Published Online: 29 MAY 2012
  2. Published Print: 13 JUL 2012

ISBN Information

Print ISBN: 9780470972441

Online ISBN: 9781118325421

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Keywords:

  • sulfonamide antibiotics, targeting metabolic processes;
  • sulfonamide antibacterials, and folic acid synthesis inhibition;
  • sulfonamide resistance, from folP gene mutation;
  • sulfonamide antibiotics, therapeutic indications;
  • sulfonamide synthesis via nucleophilic substitution;
  • sulfonamide oral bioavailability, on pKa acidity;
  • pKa2 and sulfonamide solubility, uptake into bacterial target;
  • folic acid synthesis interference, and sulfonamide selectivity;
  • bacterial resistance, sulfonamides against Gram negative and Gram positive;
  • ‘sulfa allergy,’ adverse reactions to sulfonamide

Summary

This chapter contains sections titled:

  • Discovery

  • Synthesis

  • Bioavailability

  • Mode of action and selectivity

  • Bacterial resistance

  • Clinical applications

  • Adverse drug reactions

  • Drug interactions

  • Recent developments

  • References