11. Sarcopenia and Frailty

  1. Alfonso J. Cruz-Jentoft2 and
  2. John E. Morley3,4
  1. Cornel C. Sieber

Published Online: 27 JUL 2012

DOI: 10.1002/9781118338032.ch11



How to Cite

Sieber, C. C. (2012) Sarcopenia and Frailty, in Sarcopenia (eds A. J. Cruz-Jentoft and J. E. Morley), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781118338032.ch11

Editor Information

  1. 2

    Servicio de Geriatría, Hospital Universitario Ramón y Cajal, Madrid, Spain

  2. 3

    Division of Geriatric Medicine, Saint Louis University School of Medicine, St. Louis, MO, USA

  3. 4

    Division of Endocrinology, Saint Louis University School of Medicine, St. Louis, MO, USA

Author Information

  1. Institute for Biomedicine of Ageing, Friedrich-Alexander-University Erlangen-Nürnberg, Germany

Publication History

  1. Published Online: 27 JUL 2012
  2. Published Print: 30 AUG 2012

ISBN Information

Print ISBN: 9781119975878

Online ISBN: 9781118338032



  • sarcopenia and frailty syndrome, between nutrition and frailty;
  • sarcopenia, frailty, cachexia, pathways, sarcopenia, a part of cachexia;
  • continuous loss of muscle mass with aging, in populations;
  • loss of muscle mass/strength, established links;
  • sarcopenia with less-than-expected mass, of age/gender/race;
  • sarcopenia, beyond muscle mass loss/locomotion;
  • frailty syndrome, multidimensional, physical, psycho/socio components;
  • Fried et al. criteria, for phenotypic definition of frailty;
  • sarcopenia, needing therapeutics different from cachexia;
  • pathophysiologic overlaps of sarcopenia/frailty, important


This chapter contains sections titled:

  • Introduction

  • Sarcopenia

  • Definition of Frailty

  • Future Challenges

  • Conclusions

  • References