3. Muscle Biology and mTORC1 Signaling in Aging

  1. Alfonso J. Cruz-Jentoft3 and
  2. John E. Morley4,5
  1. Blake B. Rasmussen1 and
  2. Elena Volpi2

Published Online: 27 JUL 2012

DOI: 10.1002/9781118338032.ch3

Sarcopenia

Sarcopenia

How to Cite

Rasmussen, B. B. and Volpi, E. (2012) Muscle Biology and mTORC1 Signaling in Aging, in Sarcopenia (eds A. J. Cruz-Jentoft and J. E. Morley), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781118338032.ch3

Editor Information

  1. 3

    Servicio de Geriatría, Hospital Universitario Ramón y Cajal, Madrid, Spain

  2. 4

    Division of Geriatric Medicine, Saint Louis University School of Medicine, St. Louis, MO, USA

  3. 5

    Division of Endocrinology, Saint Louis University School of Medicine, St. Louis, MO, USA

Author Information

  1. 1

    Department of Nutrition & Metabolism, Sealy Center on Aging, University of TX Medical Branch, Galveston, TX, USA

  2. 2

    Department of Internal Medicine, Division of Geriatrics, Sealy Center on Aging, University of TX Medical Branch, Galveston, TX, USA

Publication History

  1. Published Online: 27 JUL 2012
  2. Published Print: 30 AUG 2012

ISBN Information

Print ISBN: 9781119975878

Online ISBN: 9781118338032

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Keywords:

  • muscle biology and mTORC1 signaling in aging;
  • sarcopenia etiology, multifactorial, not completely understood;
  • cellular mechanisms and sarcopenia, evidence-based interventions;
  • basic mechanisms, impact on muscle protein homeostasis;
  • aging, and muscle protein turnover;
  • mTORC1 signaling pathway regulation, muscle protein turnover;
  • mTORC1 signaling, muscle protein synthesis in humans;
  • nutrition, anabolic for skeletal muscle proteins;
  • impaired muscle protein anabolism, vasodilation in the young/old;
  • exercise/nutrition and mTORC1/muscle protein, counteracting sarcopenia

Summary

This chapter contains sections titled:

  • Introduction

  • Muscle Protein Turnover in Aging

  • Regulation of Muscle Protein Turnover by the mTORC1 Signaling Pathway

  • Aging and the Impaired Muscle Protein Response to Anabolic Stimuli

  • Other Contributors to Impaired Muscle Protein Anabolism

  • Clinical Interventions to Counteract Sarcopenia

  • Summary

  • Acknowledgements

  • References