9. A Lifecourse Approach to Sarcopenia

  1. Alfonso J. Cruz-Jentoft2 and
  2. John E. Morley3,4
  1. Avan Aihie Sayer

Published Online: 27 JUL 2012

DOI: 10.1002/9781118338032.ch9



How to Cite

Sayer, A. A. (2012) A Lifecourse Approach to Sarcopenia, in Sarcopenia (eds A. J. Cruz-Jentoft and J. E. Morley), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781118338032.ch9

Editor Information

  1. 2

    Servicio de Geriatría, Hospital Universitario Ramón y Cajal, Madrid, Spain

  2. 3

    Division of Geriatric Medicine, Saint Louis University School of Medicine, St. Louis, MO, USA

  3. 4

    Division of Endocrinology, Saint Louis University School of Medicine, St. Louis, MO, USA

Author Information

  1. Academic Geriatric Medicine, MRC Lifecourse Epidemiology Unit, University of Southampton, Southampton, UK

Publication History

  1. Published Online: 27 JUL 2012
  2. Published Print: 30 AUG 2012

ISBN Information

Print ISBN: 9781119975878

Online ISBN: 9781118338032



  • sarcopenia lifecourse approach, determining loss and birth cohorts;
  • sarcopenia, skeletal muscle mass loss/function with age;
  • adverse influence in utero, infancy, on physiology;
  • developmental origins of health/disease, and developmental plasticity;
  • The Avon Longitudinal Study of Parents and Children;
  • age-related loss of muscle strength/or reduced physical performance;
  • Hertfordshire Cohort Study, grip strength as sarcopenia marker, HRQoL;
  • the Hertfordshire Ageing Study, on birth weight/adult grip link;
  • muscle size measure, direct using pQCT;
  • maternal diet, on neonatal/childhood grip strength


This chapter contains sections titled:

  • Introduction

  • A Lifecourse Approach

  • Use of Birth Cohorts

  • Lifecourse Consequences of Sarcopenia

  • Lifecourse Determinants of Sarcopenia

  • Size at Birth

  • Early Nutrition

  • Cellular and Molecular Mechanisms

  • Relevance of a Lifecourse Approach to Clinical Practice

  • Conclusion

  • References