5. Growth Factors
Published Online: 4 JUL 2012
Copyright © 2013 John Wiley & Sons, Ltd.
Basics of Blood Management, Second edition
How to Cite
Seeber, P. and Shander, A. (2012) Growth Factors, in Basics of Blood Management, Second edition, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118338070.ch5
- Published Online: 4 JUL 2012
- Published Print: 24 AUG 2012
Print ISBN: 9780470670705
Online ISBN: 9781118338070
- Colony stimulating factor;
- Thrombopoietin receptor agonist;
Human hematopoiesis is regulated by an intricate system that regulates growth, maturation, and death of hematopoietic cells. In health, this enables the hematopoietic system to adapt to the needs of the organism. The idea of modulating such systems in disease is intriguing. In fact, it has been possible to treat certain conditions such as thrombopenia and leukopenia. Agents such as granulocyte–colony stimulating factor, granulocyte–macrophage colony stimulating factor, thrombopoietin, interleukin 11, eltrombopag, or romiplostim are promising agents to enhance the endogenous hematopoietic potential. This chapter gives a brief description of the current quest for agents to modify hematopoiesis. It identifies which agents are currently available for blood management and where further work is needed.