5. Growth Factors

  1. Petra Seeber MD1 and
  2. Aryeh Shander MD, FCCM, FCCP2,3

Published Online: 4 JUL 2012

DOI: 10.1002/9781118338070.ch5

Basics of Blood Management, Second edition

Basics of Blood Management, Second edition

How to Cite

Seeber, P. and Shander, A. (2012) Growth Factors, in Basics of Blood Management, Second edition, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118338070.ch5

Author Information

  1. 1

    Institute for Blood Management, Gotha, Germany

  2. 2

    Critical Care Medicine and Hyperbaric Medicine, Englewood Hospital and Medical Center, Englewood, NJ, USA

  3. 3

    Mount Sinai School of Medicine, Mount Sinai Hospital, New York, NY, USA

Publication History

  1. Published Online: 4 JUL 2012
  2. Published Print: 24 AUG 2012

ISBN Information

Print ISBN: 9780470670705

Online ISBN: 9781118338070

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Keywords:

  • Colony stimulating factor;
  • Thrombopoietin;
  • Thrombopoietin receptor agonist;
  • Hematopoiesis;
  • Megakaryopoiesis;
  • Leucopoiesis;
  • Thrombopenia;
  • Leukopenia

Summary

Human hematopoiesis is regulated by an intricate system that regulates growth, maturation, and death of hematopoietic cells. In health, this enables the hematopoietic system to adapt to the needs of the organism. The idea of modulating such systems in disease is intriguing. In fact, it has been possible to treat certain conditions such as thrombopenia and leukopenia. Agents such as granulocyte–colony stimulating factor, granulocyte–macrophage colony stimulating factor, thrombopoietin, interleukin 11, eltrombopag, or romiplostim are promising agents to enhance the endogenous hematopoietic potential. This chapter gives a brief description of the current quest for agents to modify hematopoiesis. It identifies which agents are currently available for blood management and where further work is needed.