7. Chemistry of Hemostasis

  1. Petra Seeber MD1 and
  2. Aryeh Shander MD, FCCM, FCCP2,3

Published Online: 4 JUL 2012

DOI: 10.1002/9781118338070.ch7

Basics of Blood Management, Second edition

Basics of Blood Management, Second edition

How to Cite

Seeber, P. and Shander, A. (2012) Chemistry of Hemostasis, in Basics of Blood Management, Second edition, Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118338070.ch7

Author Information

  1. 1

    Institute for Blood Management, Gotha, Germany

  2. 2

    Critical Care Medicine and Hyperbaric Medicine, Englewood Hospital and Medical Center, Englewood, NJ, USA

  3. 3

    Mount Sinai School of Medicine, Mount Sinai Hospital, New York, NY, USA

Publication History

  1. Published Online: 4 JUL 2012
  2. Published Print: 24 AUG 2012

ISBN Information

Print ISBN: 9780470670705

Online ISBN: 9781118338070



  • Hemostasis;
  • Desmopressin;
  • Antifibrinolytics;
  • Vitamin K;
  • Conjugated estrogens;
  • Fibrin glue;
  • Tissue adhesives;
  • Hyperfibrinolysis


All bleeding eventually stops, but it is a matter of timing whether the patient experiences this phenomenon dead or alive. The faster, the more complete, and the more proficient the hemostasis, the better is the patient's chance of recovery. Mere chemistry may help to achieve such timely hemostasis. Systemically administrable drugs, such as tranexamic acid, ε-aminocaproic acid, or desmopressin are available to enhance endogenous coagulation factor production, function, and release. Some drugs are able to modify fibrinolysis and enhance platelet function. There are also drugs that promote local hemostasis. This chapter introduces the reader to practical ways to use such agents to improve the patient's outcome.