10. Specific and Nonspecific Regulation of GPCR Function by Cholesterol
- Irena Levitan2 and
- Francisco J. Barrantes3
Published Online: 22 JUN 2012
Copyright © 2012 John Wiley & Sons, Inc.
Cholesterol Regulation of Ion Channels and Receptors
How to Cite
Gimpl, G. and Gehrig-Burger, K. (2012) Specific and Nonspecific Regulation of GPCR Function by Cholesterol, in Cholesterol Regulation of Ion Channels and Receptors (eds I. Levitan and F. J. Barrantes), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118342312.ch10
Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA
Facultad de Ciencias Médicas, Pontificia Universidad Católica Argentina, Aires, Argentina
- Published Online: 22 JUN 2012
- Published Print: 16 JUL 2012
Print ISBN: 9780470874325
Online ISBN: 9781118342312
- GPCR function by cholesterol, specific and nonspecific regulation;
- heptahelical GPCRs, forming the largest receptor superfamily;
- cholesterol-binding motifs, for checking for GPCRs;
- cholesterol content in living cells, cholesterol–MβCD as donors, for depleted cells;
- cyclodextrin-based exchanges, membrane protein cholesterol specificity by SAR
This chapter contains sections titled:
Presence of Cholesterol-Binding Domains?
Presence of Cholesterol-Rich Microdomains?
Alterations in Protein Function Induced by Changes in the Cholesterol Content in Membranes/Cells?
Alterations in Receptor Function, Following Substitution of Cholesterol by Sterol Analogs? Correlation of Receptor Function with Membrane Parameters, E.G., Membrane Fluidity?
Cholesterol-Binding Molecules as Functional “Cholesterol Competitors”?
Cholesterol Requirement for Heterologous (OVER) Expression, Solubilization, and Purification of Receptors?
Direct Interaction of the Receptor with Labeled Cholesterol Probes?