12. Membrane Cholesterol: Implications in Receptor Function

  1. Irena Levitan2 and
  2. Francisco J. Barrantes3
  1. Sandeep Shrivastava and
  2. Amitabha Chattopadhyay

Published Online: 22 JUN 2012

DOI: 10.1002/9781118342312.ch12

Cholesterol Regulation of Ion Channels and Receptors

Cholesterol Regulation of Ion Channels and Receptors

How to Cite

Shrivastava, S. and Chattopadhyay, A. (2012) Membrane Cholesterol: Implications in Receptor Function, in Cholesterol Regulation of Ion Channels and Receptors (eds I. Levitan and F. J. Barrantes), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118342312.ch12

Editor Information

  1. 2

    Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA

  2. 3

    Facultad de Ciencias Médicas, Pontificia Universidad Católica Argentina, Aires, Argentina

Author Information

  1. Centre for Cellular and Molecular Biology, Council of Scientific and Industrial Research, Hyderabad, India

Publication History

  1. Published Online: 22 JUN 2012
  2. Published Print: 16 JUL 2012

ISBN Information

Print ISBN: 9780470874325

Online ISBN: 9781118342312

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Keywords:

  • membrane cholesterol, implications in receptor function;
  • cholesterol structure, membrane, GPCRs as target for novel drug candidates;
  • structure and orientation of cholesterol, nonrandom distribution in domains;
  • specialized domains, membrane cholesterol in host–pathogen interactions;
  • cholesterol depletion and statins, chronic depletion on human serotonin1A

Summary

This chapter contains sections titled:

  • Cholesterol: Structure and Membrane Organization

  • Membrane Cholesterol in the Context of Receptor Function: The Serotonin1A Receptor

  • Acute Versus Chronic Cholesterol Depletion

  • Cholesterol Binding Site(s) in GPCRS

  • Conclusion and the Road Ahead: Implications in Pathogen Entry

  • Acknowledgments

  • References