2. Cholesterol Regulation of Membrane Protein Function by Changes in Bilayer Physical Properties—An Energetic Perspective

  1. Irena Levitan3 and
  2. Francisco J. Barrantes4
  1. Jens A. Lundbæk1,2 and
  2. Olaf S. Andersen1

Published Online: 22 JUN 2012

DOI: 10.1002/9781118342312.ch2

Cholesterol Regulation of Ion Channels and Receptors

Cholesterol Regulation of Ion Channels and Receptors

How to Cite

Lundbæk, J. A. and Andersen, O. S. (2012) Cholesterol Regulation of Membrane Protein Function by Changes in Bilayer Physical Properties—An Energetic Perspective, in Cholesterol Regulation of Ion Channels and Receptors (eds I. Levitan and F. J. Barrantes), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118342312.ch2

Editor Information

  1. 3

    Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA

  2. 4

    Facultad de Ciencias Médicas, Pontificia Universidad Católica Argentina, Aires, Argentina

Author Information

  1. 1

    Department of Physiology and Biophysics, Weill Cornell Medical College, New York, NY, USA

  2. 2

    The Biomembrane Group, Department of Physics, Danish Technical University, Kgs. Lyngby, Denmark

Publication History

  1. Published Online: 22 JUN 2012
  2. Published Print: 16 JUL 2012

ISBN Information

Print ISBN: 9780470874325

Online ISBN: 9781118342312

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Keywords:

  • cholesterol regulation and bilayer properties, qualitative on/off switch;
  • lipid bilayers and cholesterol effects, for embedded proteins;
  • bilayer physical properties, and energetic analysis of changes;
  • methods, identifying specific cholesterol–protein interactions;
  • membrane protein cholesterol regulation, cholesterol-induced changes

Summary

This chapter contains sections titled:

  • Introduction

  • Cholesterol Regulation of Membrane Proteins: Possible Mechanisms

  • Protein Regulation by Cholesterol-Induced Changes in Bilayer Physical Properties

  • Cholesterol-Induced Changes in ΔGbilayerI[RIGHTWARDS ARROW]II — Quantitative Estimates

  • Methods for Identifying Protein Regulation by Changes in Bilayer Physical Properties

  • Cholesterol Regulation of Membrane Proteins in Living Cells

  • Physiological Role of Cholesterol-Induced Changes in Bilayer Physical Properties

  • Conclusion

  • References