4. Role of Lipid Rafts in the Regulation of Store-Operated Ca2+ Channels

  1. Irena Levitan2 and
  2. Francisco J. Barrantes3
  1. Hwei L. Ong and
  2. Indu S. Ambudkar

Published Online: 22 JUN 2012

DOI: 10.1002/9781118342312.ch4

Cholesterol Regulation of Ion Channels and Receptors

Cholesterol Regulation of Ion Channels and Receptors

How to Cite

Ong, H. L. and Ambudkar, I. S. (2012) Role of Lipid Rafts in the Regulation of Store-Operated Ca2+ Channels, in Cholesterol Regulation of Ion Channels and Receptors (eds I. Levitan and F. J. Barrantes), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118342312.ch4

Editor Information

  1. 2

    Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA

  2. 3

    Facultad de Ciencias Médicas, Pontificia Universidad Católica Argentina, Aires, Argentina

Author Information

  1. Molecular Physiology and Therapeutics Branch, NIDCR, NIH, Bethesda, MD, USA

Publication History

  1. Published Online: 22 JUN 2012
  2. Published Print: 16 JUL 2012

ISBN Information

Print ISBN: 9780470874325

Online ISBN: 9781118342312

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Keywords:

  • lipid rafts in store-operated Ca2+ channel regulation;
  • spatial constraints of microdomain, Ca2+ signal by SOCE, minimizing diffusion;
  • LRD in TRPC1 regulation, and Cav-1 in SOCE;
  • assembly of TRPC1 with signaling proteins within LRDs, channel gating;
  • lipid rafts and SOCE-associated calcium signaling, potential role to be identified

Summary

This chapter contains sections titled:

  • Introduction

  • Molecular Components of SOCE

  • Lipid Raft Domains and Caveolae

  • The Role of Lipid Raft Domains in the Regulation of TRPC1

  • Molecular Complexity in the Regulation of SOCE

  • Conclusions

  • References