8. Indirect Channel Regulation by Cholesterol: The Role of Caveolae and Caveolins in Regulating KATP Channel Function

  1. Irena Levitan2 and
  2. Francisco J. Barrantes3
  1. Caroline Dart

Published Online: 22 JUN 2012

DOI: 10.1002/9781118342312.ch8

Cholesterol Regulation of Ion Channels and Receptors

Cholesterol Regulation of Ion Channels and Receptors

How to Cite

Dart, C. (2012) Indirect Channel Regulation by Cholesterol: The Role of Caveolae and Caveolins in Regulating KATP Channel Function, in Cholesterol Regulation of Ion Channels and Receptors (eds I. Levitan and F. J. Barrantes), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118342312.ch8

Editor Information

  1. 2

    Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA

  2. 3

    Facultad de Ciencias Médicas, Pontificia Universidad Católica Argentina, Aires, Argentina

Author Information

  1. Institute of Integrative Biology, University of Liverpool, Liverpool, United Kingdom

Publication History

  1. Published Online: 22 JUN 2012
  2. Published Print: 16 JUL 2012

ISBN Information

Print ISBN: 9780470874325

Online ISBN: 9781118342312

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Keywords:

  • indirect channel regulation by cholesterol, caveolae/caveolins in KATP regulation;
  • KATP channels, protective roles in metabolic stress from hypoglycemia;
  • KATP channel mutation, and absent, overactive, linked to diseases;
  • KATP channel regulation and caveolae/caveolin interaction;
  • caveolin and KATP in kinetic “silencing” altering sensitivity to MgADP

Summary

This chapter contains sections titled:

  • Introduction

  • KATP Channels: Structure and Multilayered Regulation

  • Concluding Remarks and Future Directions

  • References