9. Regulation of the Nicotinic Acetylcholine Receptor by Cholesterol as a Boundary Lipid

  1. Irena Levitan1 and
  2. Francisco J. Barrantes2
  1. Francisco J. Barrantes

Published Online: 22 JUN 2012

DOI: 10.1002/9781118342312.ch9

Cholesterol Regulation of Ion Channels and Receptors

Cholesterol Regulation of Ion Channels and Receptors

How to Cite

Barrantes, F. J. (2012) Regulation of the Nicotinic Acetylcholine Receptor by Cholesterol as a Boundary Lipid, in Cholesterol Regulation of Ion Channels and Receptors (eds I. Levitan and F. J. Barrantes), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118342312.ch9

Editor Information

  1. 1

    Department of Medicine, University of Illinois at Chicago, Chicago, IL, USA

  2. 2

    Facultad de Ciencias Médicas, Pontificia Universidad Católica Argentina, Aires, Argentina

Author Information

  1. Facultad de Ciencias Médicas, Pontificia Universidad Católica Argentina, Aires, Argentina

Publication History

  1. Published Online: 22 JUN 2012
  2. Published Print: 16 JUL 2012

ISBN Information

Print ISBN: 9780470874325

Online ISBN: 9781118342312

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Keywords:

  • cholesterol regulation of receptors;
  • nicotinic acetylcholine receptor regulation by cholesterol, as boundary lipid;
  • AChR–lipid interactions, cholesterol and AChR cross-talk;
  • cholesterol on AChR, CRAC, with AChR docked on TM1, TM3, TM4;
  • cholesterol and PA, agonist-induced transitions, AChR as novel conformation

Summary

This chapter contains sections titled:

  • Introduction

  • The AChR is Surrounded by Lipids in the Liquid-Ordered Phase

  • Stoichiometry and Selectivity of the Protein-Vicinal Lipid

  • Influence of Cholesterol on AChR Secondary Structure

  • Influence of Cholesterol on Agonist-Induced Conformational States and Ion Translocation Function

  • The Common “Three-Ring” Scaffold in Cys-Loop Receptor Transmembrane Topology: From Bacterial Homologs to Eukaryotes

  • Cholesterol Binding to Nonannular Sites on the AChR Molecule

  • A New Cholesterol-Recognition Motif in the AChR is also Present in GPCRs

  • Acknowledgments

  • References