1. C–H Functionalization: A New Strategy for the Synthesis of Biologically Active Natural Products

  1. Janine Cossy and
  2. Stellios Arseniyadis
  1. Sophie Rousseaux,
  2. Benoît Liégault and
  3. Keith Fagnou

Published Online: 30 AUG 2012

DOI: 10.1002/9781118342886.ch1

Modern Tools for the Synthesis of Complex Bioactive Molecules

Modern Tools for the Synthesis of Complex Bioactive Molecules

How to Cite

Rousseaux, S., Liégault, B. and Fagnou, K. (2012) C–H Functionalization: A New Strategy for the Synthesis of Biologically Active Natural Products, in Modern Tools for the Synthesis of Complex Bioactive Molecules (eds J. Cossy and S. Arseniyadis), John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118342886.ch1

Editor Information

  1. Laboratoire de Chimie Organique, UMR 7084 CNRS ESPCI, ParisTech, Paris, France

Author Information

  1. Department of Chemistry, University of Ottawa, Ottawa, Ontario, Canada

Publication History

  1. Published Online: 30 AUG 2012
  2. Published Print: 21 SEP 2012

ISBN Information

Print ISBN: 9780470616185

Online ISBN: 9781118342886

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Keywords:

  • C–H functionalization, biologically active natural products;
  • transition metal-catalyzed transformations, at C–H bonds;
  • carbon–carbon and carbon–heteroatom bonds;
  • mechanism of C–H bond cleavage in processes

Summary

This chapter contains sections titled

  • Introduction

  • Palladium(0)-Catalyzed Intramolecular Direct Arylation

  • Palladium(0)-Catalyzed Intramolecular Alkenylation of sp2 C-H Bonds

  • Palladium(0)-Catalyzed Intramolecular Arylation of sp3 C-H Bonds

  • Palladium(Ii)-Mediated Intramolecular Oxidative Alkenylation of sp2 C-H Bonds

  • Directing Group-Assisted Palladium(II)-Enabled Carbon-Carbon Bond Formation at sp3 C-H Bonds

  • Platinum(Ii)-Mediated Alkane Dehydrogenation

  • Palladium(Ii)-Enabled Carbon-Oxygen Bond Formation at sp3 C-H Bonds

  • Iridium-Catalyzed Borylation of sp2 C-H Bonds

  • Rhodium(I)-Catalyzed Intramolecular Directed Alkylation of sp2 C-H Bonds

  • Rhodium(III)-Catalyzed Synthesis of Nitrogen-Containing Heterocycles

  • Conclusion

  • References