1. Concept and Scope of Modern Vaccines

  1. W. John W. Morrow PhD, DSc, FRCPath1,
  2. Nadeem A. Sheikh PhD2,
  3. Clint S. Schmidt PhD3 and
  4. D. Huw Davies PhD4
  1. D. Huw Davies PhD4,
  2. Clint S. Schmidt PhD3 and
  3. Nadeem A. Sheikh PhD2

Published Online: 20 JUN 2012

DOI: 10.1002/9781118345313.ch1

Vaccinology: Principles and Practice

Vaccinology: Principles and Practice

How to Cite

Davies, D. H., Schmidt, C. S. and Sheikh, N. A. (2012) Concept and Scope of Modern Vaccines, in Vaccinology: Principles and Practice (eds W. J. W. Morrow, N. A. Sheikh, C. S. Schmidt and D. H. Davies), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118345313.ch1

Editor Information

  1. 1

    Seattle, WA, USA

  2. 2

    Dendreon Corporation, Seattle, WA, USA

  3. 3

    NovaDigm Therapeutics, Inc., Grand Forks, ND, USA

  4. 4

    University of California at Irvine, Irvine, CA, USA

Author Information

  1. 2

    Dendreon Corporation, Seattle, WA, USA

  2. 3

    NovaDigm Therapeutics, Inc., Grand Forks, ND, USA

  3. 4

    University of California at Irvine, Irvine, CA, USA

Publication History

  1. Published Online: 20 JUN 2012
  2. Published Print: 3 AUG 2012

ISBN Information

Print ISBN: 9781405185745

Online ISBN: 9781118345313

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Keywords:

  • modern vaccines;
  • scope;
  • development;
  • adjuvant;
  • reverse-vaccinology

Summary

Traditional approaches to vaccine design were to weaken or inactivate the human pathogen or a related animal homologue. While effective, many such vaccines come with unacceptable risks of adverse events, and the risk of causing rather than preventing disease. The need for safer vaccines that are effective and affordable is being met in the post-genomic era by DNA-based approaches. Modern vaccines demand a clearer understanding of the rules that underlie antigenicity, immunogenicity, adjuvanticity, and immunologic memory. Moreover, some pathogens with complex genomes or life cycles provide many more challenges to genome-based vaccine development than simpler pathogens such as viruses. In this brief overview we examine the scope of modern vaccines and the challenges, both new and old, to their development.