1. Concept and Scope of Modern Vaccines
- W. John W. Morrow PhD, DSc, FRCPath1,
- Nadeem A. Sheikh PhD2,
- Clint S. Schmidt PhD3,
- D. Huw Davies PhD4
Published Online: 20 JUN 2012
DOI: 10.1002/9781118345313.ch1
Copyright © 2012 Blackwell Publishing Ltd
Book Title
Vaccinology: Principles and Practice
Additional Information
How to Cite
Davies, D. H., Schmidt, C. S. and Sheikh, N. A. (2012) Concept and Scope of Modern Vaccines, in Vaccinology: Principles and Practice (eds W. J. W. Morrow, N. A. Sheikh, C. S. Schmidt and D. H. Davies), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118345313.ch1
Editor Information
- 1
Seattle, WA, USA
- 2
Dendreon Corporation, Seattle, WA, USA
- 3
NovaDigm Therapeutics, Inc., Grand Forks, ND, USA
- 4
University of California at Irvine, Irvine, CA, USA
Publication History
- Published Online: 20 JUN 2012
- Published Print: 3 AUG 2012
ISBN Information
Print ISBN: 9781405185745
Online ISBN: 9781118345313
- Summary
- Chapter
- References
Keywords:
- modern vaccines;
- scope;
- development;
- adjuvant;
- reverse-vaccinology
Summary
Traditional approaches to vaccine design were to weaken or inactivate the human pathogen or a related animal homologue. While effective, many such vaccines come with unacceptable risks of adverse events, and the risk of causing rather than preventing disease. The need for safer vaccines that are effective and affordable is being met in the post-genomic era by DNA-based approaches. Modern vaccines demand a clearer understanding of the rules that underlie antigenicity, immunogenicity, adjuvanticity, and immunologic memory. Moreover, some pathogens with complex genomes or life cycles provide many more challenges to genome-based vaccine development than simpler pathogens such as viruses. In this brief overview we examine the scope of modern vaccines and the challenges, both new and old, to their development.