21. Needle-Free Jet Injection for Vaccine Administration

  1. W. John W. Morrow PhD, DSc, FRCPath3,
  2. Nadeem A. Sheikh PhD4,
  3. Clint S. Schmidt PhD5 and
  4. D. Huw Davies PhD6
  1. Brian R. Sloat1,
  2. Hoi K. Tran2 and
  3. Zhengrong Cui1

Published Online: 20 JUN 2012

DOI: 10.1002/9781118345313.ch21

Vaccinology: Principles and Practice

Vaccinology: Principles and Practice

How to Cite

Sloat, B. R., Tran, H. K. and Cui, Z. (2012) Needle-Free Jet Injection for Vaccine Administration, in Vaccinology: Principles and Practice (eds W. J. W. Morrow, N. A. Sheikh, C. S. Schmidt and D. H. Davies), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118345313.ch21

Editor Information

  1. 3

    Seattle, WA, USA

  2. 4

    Dendreon Corporation, Seattle, WA, USA

  3. 5

    NovaDigm Therapeutics, Inc., Grand Forks, ND, USA

  4. 6

    University of California at Irvine, Irvine, CA, USA

Author Information

  1. 1

    Pharmaceutics Division, College of Pharmacy, University of Texas-Austin, Austin, USA

  2. 2

    Department of Pharmaceutical Sciences, College of Pharmacy, Oregon State University, Corvallis, OR, USA

Publication History

  1. Published Online: 20 JUN 2012
  2. Published Print: 3 AUG 2012

ISBN Information

Print ISBN: 9781405185745

Online ISBN: 9781118345313



  • liquid jet injector;
  • solid jet injector;
  • immune responses;
  • safety


Although being an effective method to administer vaccines, needle and syringe based injection has its limitations, which promoted the development of needle-free devices to inject vaccines. Needle-free injection can be advantageous to patients, medical personnel, and the community. It may also help lower the cost of vaccines and is amenable for mass immunization. Liquid jet injectors and solid jet injectors are the two notable categories of needle-free injection devices with proven efficacy in preclinical and clinical trials. In this chapter, we briefly describe these devices and their mechanisms of action, their application in vaccine delivery and the resultant immune responses, and finally their limitations. We conclude that the future of needle-free injection devices holds many promises as well as room for improvement.