21. Needle-Free Jet Injection for Vaccine Administration
- W. John W. Morrow PhD, DSc, FRCPath3,
- Nadeem A. Sheikh PhD4,
- Clint S. Schmidt PhD5,
- D. Huw Davies PhD6
Published Online: 20 JUN 2012
DOI: 10.1002/9781118345313.ch21
Copyright © 2012 Blackwell Publishing Ltd
Book Title
Vaccinology: Principles and Practice
Additional Information
How to Cite
Sloat, B. R., Tran, H. K. and Cui, Z. (2012) Needle-Free Jet Injection for Vaccine Administration, in Vaccinology: Principles and Practice (eds W. J. W. Morrow, N. A. Sheikh, C. S. Schmidt and D. H. Davies), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118345313.ch21
Editor Information
- 3
Seattle, WA, USA
- 4
Dendreon Corporation, Seattle, WA, USA
- 5
NovaDigm Therapeutics, Inc., Grand Forks, ND, USA
- 6
University of California at Irvine, Irvine, CA, USA
Publication History
- Published Online: 20 JUN 2012
- Published Print: 3 AUG 2012
ISBN Information
Print ISBN: 9781405185745
Online ISBN: 9781118345313
- Summary
- Chapter
- References
Keywords:
- liquid jet injector;
- solid jet injector;
- immune responses;
- safety
Summary
Although being an effective method to administer vaccines, needle and syringe based injection has its limitations, which promoted the development of needle-free devices to inject vaccines. Needle-free injection can be advantageous to patients, medical personnel, and the community. It may also help lower the cost of vaccines and is amenable for mass immunization. Liquid jet injectors and solid jet injectors are the two notable categories of needle-free injection devices with proven efficacy in preclinical and clinical trials. In this chapter, we briefly describe these devices and their mechanisms of action, their application in vaccine delivery and the resultant immune responses, and finally their limitations. We conclude that the future of needle-free injection devices holds many promises as well as room for improvement.