22. Oral Vaccines: An Old Need and Some New Possibilities

  1. W. John W. Morrow PhD, DSc, FRCPath2,
  2. Nadeem A. Sheikh PhD3,
  3. Clint S. Schmidt PhD4 and
  4. D. Huw Davies PhD5
  1. Amit A. Lugade PhD,
  2. Kalathil Suresh PhD and
  3. Yasmin Thanavala PhD

Published Online: 20 JUN 2012

DOI: 10.1002/9781118345313.ch22

Vaccinology: Principles and Practice

Vaccinology: Principles and Practice

How to Cite

Lugade, A. A., Suresh, K. and Thanavala, Y. (2012) Oral Vaccines: An Old Need and Some New Possibilities, in Vaccinology: Principles and Practice (eds W. J. W. Morrow, N. A. Sheikh, C. S. Schmidt and D. H. Davies), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118345313.ch22

Editor Information

  1. 2

    Seattle, WA, USA

  2. 3

    Dendreon Corporation, Seattle, WA, USA

  3. 4

    NovaDigm Therapeutics, Inc., Grand Forks, ND, USA

  4. 5

    University of California at Irvine, Irvine, CA, USA

Author Information

  1. Department of Immunology, Roswell Park Cancer Institute, Buffalo, NY, USA

Publication History

  1. Published Online: 20 JUN 2012
  2. Published Print: 3 AUG 2012

ISBN Information

Print ISBN: 9781405185745

Online ISBN: 9781118345313



  • vaccines;
  • oral delivery;
  • tolerance;
  • immune responses;
  • transgenic plants;
  • clinical trial


Oral vaccines offer significant advantages as the polio eradication campaign has demonstrated, over delivery via needle and syringe. Additionally, mucosal immunity generated by oral vaccines, along with systemic immunity, can provide an important means of controlling infections that are caused by pathogens that infect the gut mucosa. There are a number of approaches being evaluated to deliver vaccines orally and efforts are also being devoted to understand the mechanism of determining the generation of oral immunity and overcoming oral tolerance.