22. Oral Vaccines: An Old Need and Some New Possibilities
- W. John W. Morrow PhD, DSc, FRCPath2,
- Nadeem A. Sheikh PhD3,
- Clint S. Schmidt PhD4,
- D. Huw Davies PhD5
Published Online: 20 JUN 2012
DOI: 10.1002/9781118345313.ch22
Copyright © 2012 Blackwell Publishing Ltd
Book Title
Vaccinology: Principles and Practice
Additional Information
How to Cite
Lugade, A. A., Suresh, K. and Thanavala, Y. (2012) Oral Vaccines: An Old Need and Some New Possibilities, in Vaccinology: Principles and Practice (eds W. J. W. Morrow, N. A. Sheikh, C. S. Schmidt and D. H. Davies), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118345313.ch22
Editor Information
- 2
Seattle, WA, USA
- 3
Dendreon Corporation, Seattle, WA, USA
- 4
NovaDigm Therapeutics, Inc., Grand Forks, ND, USA
- 5
University of California at Irvine, Irvine, CA, USA
Publication History
- Published Online: 20 JUN 2012
- Published Print: 3 AUG 2012
ISBN Information
Print ISBN: 9781405185745
Online ISBN: 9781118345313
- Summary
- Chapter
- References
Keywords:
- vaccines;
- oral delivery;
- tolerance;
- immune responses;
- transgenic plants;
- clinical trial
Summary
Oral vaccines offer significant advantages as the polio eradication campaign has demonstrated, over delivery via needle and syringe. Additionally, mucosal immunity generated by oral vaccines, along with systemic immunity, can provide an important means of controlling infections that are caused by pathogens that infect the gut mucosa. There are a number of approaches being evaluated to deliver vaccines orally and efforts are also being devoted to understand the mechanism of determining the generation of oral immunity and overcoming oral tolerance.