24. Immunostimulatory Properties of Biodegradable Microparticles

  1. W. John W. Morrow PhD, DSc, FRCPath3,
  2. Nadeem A. Sheikh PhD4,
  3. Clint S. Schmidt PhD5 and
  4. D. Huw Davies PhD6
  1. Fiona A. Sharp PhD1 and
  2. Ed C. Lavelle PhD2

Published Online: 20 JUN 2012

DOI: 10.1002/9781118345313.ch24

Vaccinology: Principles and Practice

Vaccinology: Principles and Practice

How to Cite

Sharp, F. A. and Lavelle, E. C. (2012) Immunostimulatory Properties of Biodegradable Microparticles, in Vaccinology: Principles and Practice (eds W. J. W. Morrow, N. A. Sheikh, C. S. Schmidt and D. H. Davies), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118345313.ch24

Editor Information

  1. 3

    Seattle, WA, USA

  2. 4

    Dendreon Corporation, Seattle, WA, USA

  3. 5

    NovaDigm Therapeutics, Inc., Grand Forks, ND, USA

  4. 6

    University of California at Irvine, Irvine, CA, USA

Author Information

  1. 1

    Fahmy Research Group, Department of Biomedical Engineering, School of Engineering and Applied Science, Yale University, New Haven, CT, USA

  2. 2

    Adjuvant Research Group, School of Biochemistry and Immunology, Trinity Biomedical Sciences Institute, Trinity College, Dublin, Ireland

Publication History

  1. Published Online: 20 JUN 2012
  2. Published Print: 3 AUG 2012

ISBN Information

Print ISBN: 9781405185745

Online ISBN: 9781118345313

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Keywords:

  • subunit vaccine;
  • adjuvant;
  • immunostimulatory effect;
  • ISCOM;
  • immunogenicity

Summary

The development of vaccines has progressed significantly since the days of Edward Jenner and Louis Pasteur. Due to increased safety concerns and advances in molecular biology and immunology, we have moved away from the use of whole organism based vaccines and toward recombinant subunit vaccines. These subunit vaccines generally have an improved safety profile but the price paid for this is reduced immunogenicity. In order to enhance the efficacy of subunit vaccines, adjuvants are added. The inclusion of adjuvants can have several positive effects on the efficacy of vaccines, including increased stimulation of cell-mediated immunity and the promotion of mucosal immunity.