28. Immune Monitoring Design within the Developmental Pipeline for an Immunotherapeutic or Preventive Vaccine
- W. John W. Morrow PhD, DSc, FRCPath4,
- Nadeem A. Sheikh PhD5,
- Clint S. Schmidt PhD6,
- D. Huw Davies PhD7
Published Online: 20 JUN 2012
DOI: 10.1002/9781118345313.ch28
Copyright © 2012 Blackwell Publishing Ltd
Book Title
Vaccinology: Principles and Practice
Additional Information
How to Cite
Janetzki, S., Romero, P., Roederer, M., Bolton, D. L. and Jandus, C. (2012) Immune Monitoring Design within the Developmental Pipeline for an Immunotherapeutic or Preventive Vaccine, in Vaccinology: Principles and Practice (eds W. J. W. Morrow, N. A. Sheikh, C. S. Schmidt and D. H. Davies), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118345313.ch28
Editor Information
- 4
Seattle, WA, USA
- 5
Dendreon Corporation, Seattle, WA, USA
- 6
NovaDigm Therapeutics, Inc., Grand Forks, ND, USA
- 7
University of California at Irvine, Irvine, CA, USA
Publication History
- Published Online: 20 JUN 2012
- Published Print: 3 AUG 2012
ISBN Information
Print ISBN: 9781405185745
Online ISBN: 9781118345313
- Summary
- Chapter
- References
Keywords:
- immune monitoring;
- immunotherapeutic and preventive vaccines;
- bioassays;
- T cell assays;
- immune responses;
- sample logistics
Summary
Immunotherapy is defined as the treatment of disease by inducing, enhancing, or suppressing an immune response, whereas preventive vaccination is intended to prevent the development of diseases in healthy subjects. Most successful prophylactic vaccines rely on the induction of high titers of neutralizing antibodies. It is generally thought that therapeutic vaccination requires induction of robust T-cell mediated immunity. The diverse array of potential or already in use immunotherapeutic and preventive agents all share the commonality of stimulating the immune system. Hence, measuring those vaccination-induced immune responses gives the earliest indication of vaccine take and its immune modulating effects.