5. Immunologic Memory: T Cells in Humans
- W. John W. Morrow PhD, DSc, FRCPath2,
- Nadeem A. Sheikh PhD3,
- Clint S. Schmidt PhD4,
- D. Huw Davies PhD5
Published Online: 20 JUN 2012
DOI: 10.1002/9781118345313.ch5
Copyright © 2012 Blackwell Publishing Ltd
Book Title
Vaccinology: Principles and Practice
Additional Information
How to Cite
Iglesias, M. C., Appay, V. and Moris, A. (2012) Immunologic Memory: T Cells in Humans, in Vaccinology: Principles and Practice (eds W. J. W. Morrow, N. A. Sheikh, C. S. Schmidt and D. H. Davies), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118345313.ch5
Editor Information
- 2
Seattle, WA, USA
- 3
Dendreon Corporation, Seattle, WA, USA
- 4
NovaDigm Therapeutics, Inc., Grand Forks, ND, USA
- 5
University of California at Irvine, Irvine, CA, USA
Publication History
- Published Online: 20 JUN 2012
- Published Print: 3 AUG 2012
ISBN Information
Print ISBN: 9781405185745
Online ISBN: 9781118345313
- Summary
- Chapter
- References
Keywords:
- vaccine;
- T cell subsets;
- precursor;
- polyfunctionality;
- quality;
- avidity;
- antigen;
- correlates of protection;
- DC;
- TLR
Summary
The elucidation of the basic tenets of immunological memory has paved the way for the use of vaccines. Understanding the development and maintenance of protective T lymphocyte memory responses will help in defining novel vaccination strategies. The memory T-cell compartment is made of distinct and specialized subpopulations whose functions are not clearly defined and may vary according to their pathogen specificity. Multiple parameters determine the fate of T cells and their differentiation into distinct memory subsets: the nature and strength of the signals delivered to lymphocytes during priming and the sensitivity of cells to these signals shape the type and quality of the memory T-cell responses. In this chapter, we review the various parameters that impact on memory responses, and discuss this knowledge for the induction of effective T cells with vaccines.