5. Immunologic Memory: T Cells in Humans

  1. W. John W. Morrow PhD, DSc, FRCPath2,
  2. Nadeem A. Sheikh PhD3,
  3. Clint S. Schmidt PhD4 and
  4. D. Huw Davies PhD5
  1. Maria Candela Iglesias,
  2. Victor Appay and
  3. Arnaud Moris

Published Online: 20 JUN 2012

DOI: 10.1002/9781118345313.ch5

Vaccinology: Principles and Practice

Vaccinology: Principles and Practice

How to Cite

Iglesias, M. C., Appay, V. and Moris, A. (2012) Immunologic Memory: T Cells in Humans, in Vaccinology: Principles and Practice (eds W. J. W. Morrow, N. A. Sheikh, C. S. Schmidt and D. H. Davies), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118345313.ch5

Editor Information

  1. 2

    Seattle, WA, USA

  2. 3

    Dendreon Corporation, Seattle, WA, USA

  3. 4

    NovaDigm Therapeutics, Inc., Grand Forks, ND, USA

  4. 5

    University of California at Irvine, Irvine, CA, USA

Author Information

  1. INSERM UMR S 945, Infections and Immunity, Avenir Group, Université Pierre et Marie Curie (UPMC), Sorbonne Universités, and Hôpital Pitié-Salpétrière, Paris, France

Publication History

  1. Published Online: 20 JUN 2012
  2. Published Print: 3 AUG 2012

ISBN Information

Print ISBN: 9781405185745

Online ISBN: 9781118345313

SEARCH

Keywords:

  • vaccine;
  • T cell subsets;
  • precursor;
  • polyfunctionality;
  • quality;
  • avidity;
  • antigen;
  • correlates of protection;
  • DC;
  • TLR

Summary

The elucidation of the basic tenets of immunological memory has paved the way for the use of vaccines. Understanding the development and maintenance of protective T lymphocyte memory responses will help in defining novel vaccination strategies. The memory T-cell compartment is made of distinct and specialized subpopulations whose functions are not clearly defined and may vary according to their pathogen specificity. Multiple parameters determine the fate of T cells and their differentiation into distinct memory subsets: the nature and strength of the signals delivered to lymphocytes during priming and the sensitivity of cells to these signals shape the type and quality of the memory T-cell responses. In this chapter, we review the various parameters that impact on memory responses, and discuss this knowledge for the induction of effective T cells with vaccines.