6. Immunologic Memory: B cells

  1. W. John W. Morrow PhD, DSc, FRCPath3,
  2. Nadeem A. Sheikh PhD4,
  3. Clint S. Schmidt PhD5 and
  4. D. Huw Davies PhD6
  1. F. Eun-Hyung Lee MD1 and
  2. Iñaki Sanz MD2

Published Online: 20 JUN 2012

DOI: 10.1002/9781118345313.ch6

Vaccinology: Principles and Practice

Vaccinology: Principles and Practice

How to Cite

Lee, F. E.-H. and Sanz, I. (2012) Immunologic Memory: B cells, in Vaccinology: Principles and Practice (eds W. J. W. Morrow, N. A. Sheikh, C. S. Schmidt and D. H. Davies), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118345313.ch6

Editor Information

  1. 3

    Seattle, WA, USA

  2. 4

    Dendreon Corporation, Seattle, WA, USA

  3. 5

    NovaDigm Therapeutics, Inc., Grand Forks, ND, USA

  4. 6

    University of California at Irvine, Irvine, CA, USA

Author Information

  1. 1

    Emory University Department of Medicine, Division of Pulmonary, Allergy, and Critical Care Medicine, Atlanta, GA, USA

  2. 2

    Division of Allergy, Immunology, and Rheumatology, University of Rochester Medical Center, Rochester, NY, USA

Publication History

  1. Published Online: 20 JUN 2012
  2. Published Print: 3 AUG 2012

ISBN Information

Print ISBN: 9781405185745

Online ISBN: 9781118345313

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Keywords:

  • memory B cells;
  • antibody-secreting cell;
  • plasma cell;
  • plasmablast;
  • long-lived;
  • humoral response;
  • antibody;
  • immunization;
  • vaccination;
  • human

Summary

Historical measurements of human vaccine immunity have included neutralizing antibody. These serologic immune correlates are based on the “B-cell memory response” to guarantee immediate protection to dangerous pathogens. Two compartments constitute this B-cell memory response: (i) the long-lived plasma cells that are responsible for the sustained levels of protective antibodies, and (ii) the memory B cells, which are the precursors of the plasma cell compartment. This chapter outlines specific factors important for the generation of long-lived plasma cells and the current paradigms for their maintenance. It also describes the importance of the heterogeneity of the circulating antibody-secreting cells (ASCs) and memory B cells during vaccine priming. By interrogating these particular ASC and memory B-cell subsets with historical long-lived vaccines, an understanding of new memory B-cell immune surrogates and biomarkers of effective long-lived plasma cell precursors in the blood of human subjects will be most useful to study newly developed vaccines.