6. Immunologic Memory: B cells
- W. John W. Morrow PhD, DSc, FRCPath3,
- Nadeem A. Sheikh PhD4,
- Clint S. Schmidt PhD5,
- D. Huw Davies PhD6
Published Online: 20 JUN 2012
DOI: 10.1002/9781118345313.ch6
Copyright © 2012 Blackwell Publishing Ltd
Book Title
Vaccinology: Principles and Practice
Additional Information
How to Cite
Lee, F. E.-H. and Sanz, I. (2012) Immunologic Memory: B cells, in Vaccinology: Principles and Practice (eds W. J. W. Morrow, N. A. Sheikh, C. S. Schmidt and D. H. Davies), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118345313.ch6
Editor Information
- 3
Seattle, WA, USA
- 4
Dendreon Corporation, Seattle, WA, USA
- 5
NovaDigm Therapeutics, Inc., Grand Forks, ND, USA
- 6
University of California at Irvine, Irvine, CA, USA
Publication History
- Published Online: 20 JUN 2012
- Published Print: 3 AUG 2012
ISBN Information
Print ISBN: 9781405185745
Online ISBN: 9781118345313
- Summary
- Chapter
- References
Keywords:
- memory B cells;
- antibody-secreting cell;
- plasma cell;
- plasmablast;
- long-lived;
- humoral response;
- antibody;
- immunization;
- vaccination;
- human
Summary
Historical measurements of human vaccine immunity have included neutralizing antibody. These serologic immune correlates are based on the “B-cell memory response” to guarantee immediate protection to dangerous pathogens. Two compartments constitute this B-cell memory response: (i) the long-lived plasma cells that are responsible for the sustained levels of protective antibodies, and (ii) the memory B cells, which are the precursors of the plasma cell compartment. This chapter outlines specific factors important for the generation of long-lived plasma cells and the current paradigms for their maintenance. It also describes the importance of the heterogeneity of the circulating antibody-secreting cells (ASCs) and memory B cells during vaccine priming. By interrogating these particular ASC and memory B-cell subsets with historical long-lived vaccines, an understanding of new memory B-cell immune surrogates and biomarkers of effective long-lived plasma cell precursors in the blood of human subjects will be most useful to study newly developed vaccines.