7. Utility of Mouse Models in Vaccine Design and Development

  1. W. John W. Morrow PhD, DSc, FRCPath4,
  2. Nadeem A. Sheikh PhD5,
  3. Clint S. Schmidt PhD6 and
  4. D. Huw Davies PhD7
  1. Catharine M. Bosio PhD1,
  2. Megan MacLeod PhD2,
  3. Philippa Marrack PhD2 and
  4. Ross M. Kedl PhD3

Published Online: 20 JUN 2012

DOI: 10.1002/9781118345313.ch7

Vaccinology: Principles and Practice

Vaccinology: Principles and Practice

How to Cite

Bosio, C. M., MacLeod, M., Marrack, P. and Kedl, R. M. (2012) Utility of Mouse Models in Vaccine Design and Development, in Vaccinology: Principles and Practice (eds W. J. W. Morrow, N. A. Sheikh, C. S. Schmidt and D. H. Davies), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118345313.ch7

Editor Information

  1. 4

    Seattle, WA, USA

  2. 5

    Dendreon Corporation, Seattle, WA, USA

  3. 6

    NovaDigm Therapeutics, Inc., Grand Forks, ND, USA

  4. 7

    University of California at Irvine, Irvine, CA, USA

Author Information

  1. 1

    Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT, USA

  2. 2

    Integrated Department of Immunology, Howard Hughes Medical Institute, National Jewish Health, Denver, CO, USA

  3. 3

    Department of Immunology, University of Colorado Denver, Denver, CO, USA

Publication History

  1. Published Online: 20 JUN 2012
  2. Published Print: 3 AUG 2012

ISBN Information

Print ISBN: 9781405185745

Online ISBN: 9781118345313

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Keywords:

  • scientific experimentation;
  • mouse model;
  • vaccine design and development;
  • immunologic studies

Summary

The use of the mouse as the dominant animal model for immunologic studies was due in no small part to an inner ear defect in the Japanese waltzing mouse. The tendency of these mice to, when excited, scramble around the cage in a random fashion until exhausted is caused by a single recessive gene that causes an inner ear defect, leading to the curious behavior. In the process of maintaining this behavior through many generations of breeding, mouse fanciers unwittingly, but significantly, reduced the genetic heterogeneity of the species. This reduced heterogeneity made the growth of a tumor derived from a Japanese waltzing mouse far more reproducible. Utilizing this model and knowledge in the early 1900s, investigators began mating mice for many generations, creating inbred strains of mice with known susceptibility to various diseases. These studies led to the theory of the genetic control of tumor susceptibility, and, ultimately, to the use of mice to study what would eventually become the field of immunology.

In this chapter, we discuss examples of clinically and/or experimentally relevant viral and bacterial infections that are used for the purposes of vaccine development and analysis.