1. Deep Brain Stimulation: Mechanisms of Action

  1. Sam Eljamel2 and
  2. Konstantin V. Slavin3
  1. Erwin B. Montgomery Jr.

Published Online: 19 JUL 2013

DOI: 10.1002/9781118346396.ch1

Neurostimulation: Principles and Practice

Neurostimulation: Principles and Practice

How to Cite

Montgomery, E. B. (2013) Deep Brain Stimulation: Mechanisms of Action, in Neurostimulation: Principles and Practice (eds S. Eljamel and K. V. Slavin), John Wiley & Sons, Ltd, Oxford, UK. doi: 10.1002/9781118346396.ch1

Editor Information

  1. 2

    Centre for Neurosciences, Ninewells Hospital & Medical School, Dundee, Scotland, UK

  2. 3

    Department of Neurosurgery, University of Illinois at Chicago. Chicago, Illinois, USA

Author Information

  1. University of Alabama, Birmingham, Alabama, USA

Publication History

  1. Published Online: 19 JUL 2013
  2. Published Print: 19 AUG 2013

ISBN Information

Print ISBN: 9781118346358

Online ISBN: 9781118346396



  • deep brain stimulation (DBS);
  • neural responses;
  • neuronal responses;
  • Parkinson's disease (PD);
  • pathophysiological theories


Deep brain stimulation (DBS) is arguably the most effective treatment for movement disorders, such as Parkinson's disease (PD) and dystonia. This chapter begins with an attempt to answer the question as to what is the fundamental mechanism by which the DBS injection of electrical charge affects neurons. The implications of that answer for certain theories of DBS therapeutic mechanisms are explored. The chapter discusses the pathophysiological theories of the relevant neurological disorders that provides the context for DBS research. Then, it surveys research observations regarding how individual neurons respond to the DBS pulse. A distinction is made between neuronal responses and neural responses.