23. Peripheral Nerve Stimulation in Pain of the Body and Extremities

  1. Sam Eljamel3 and
  2. Konstantin V. Slavin4
  1. Konstantin V. Slavin1,
  2. Sami Al-Nafi1 and
  3. Serge Y. Rasskazoff2

Published Online: 19 JUL 2013

DOI: 10.1002/9781118346396.ch23

Neurostimulation: Principles and Practice

Neurostimulation: Principles and Practice

How to Cite

Slavin, K. V., Al-Nafi, S. and Rasskazoff, S. Y. (2013) Peripheral Nerve Stimulation in Pain of the Body and Extremities, in Neurostimulation: Principles and Practice (eds S. Eljamel and K. V. Slavin), John Wiley & Sons, Ltd, Oxford, UK. doi: 10.1002/9781118346396.ch23

Editor Information

  1. 3

    Centre for Neurosciences, Ninewells Hospital & Medical School, Dundee, Scotland, UK

  2. 4

    Department of Neurosurgery, University of Illinois at Chicago. Chicago, Illinois, USA

Author Information

  1. 1

    University of Illinois at Chicago, Chicago, Illinois, USA

  2. 2

    Flint, Michigan, USA

Publication History

  1. Published Online: 19 JUL 2013
  2. Published Print: 19 AUG 2013

ISBN Information

Print ISBN: 9781118346358

Online ISBN: 9781118346396



  • body;
  • chronic pain;
  • extremities;
  • neuromodulation;
  • peripheral nerve field stimulation (PNFS);
  • peripheral nerve stimulation (PNS)


This chapter summarizes the current state of peripheral nerve stimulation (PNS) in treatment of chronic pain in the body and extremities. Most common indications for PNS in the extremities are chronic pain due to peripheral nerve injury, persistent pain from compressive neuropathy, complex regional pain syndromes (CRPS) type 1 (formerly known as reflex sympathetic dystrophy) and type 2 (formerly known as causalgia), and painful peripheral neuropathy. The chapter concludes that the peripheral neuromodulation approach includes the following three modalities: (1) PNS, which requires implantation of stimulating electrode leads over the affected peripheral nerves, (2) percutaneous PNS, which involves insertion of leads in the vicinity of the nerve with proper guidance, and (3) Peripheral nerve field stimulation (PNFS), which stimulates smaller nerves and nerve endings in the region of pain. It is an effective way to control chronic, disabling, medically refractory neuropathic pain of different etiologies.