3. Deep Brain Stimulation in Parkinson's Disease: Subthalamic Nucleus

  1. Sam Eljamel2 and
  2. Konstantin V. Slavin3
  1. Manish Ranjan and
  2. Christopher R. Honey

Published Online: 19 JUL 2013

DOI: 10.1002/9781118346396.ch3

Neurostimulation: Principles and Practice

Neurostimulation: Principles and Practice

How to Cite

Ranjan, M. and Honey, C. R. (2013) Deep Brain Stimulation in Parkinson's Disease: Subthalamic Nucleus, in Neurostimulation: Principles and Practice (eds S. Eljamel and K. V. Slavin), John Wiley & Sons, Ltd, Oxford, UK. doi: 10.1002/9781118346396.ch3

Editor Information

  1. 2

    Centre for Neurosciences, Ninewells Hospital & Medical School, Dundee, Scotland, UK

  2. 3

    Department of Neurosurgery, University of Illinois at Chicago. Chicago, Illinois, USA

Author Information

  1. University of British Columbia, Vancouver, British Columbia, Canada

Publication History

  1. Published Online: 19 JUL 2013
  2. Published Print: 19 AUG 2013

ISBN Information

Print ISBN: 9781118346358

Online ISBN: 9781118346396

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Keywords:

  • deep brain stimulation (DBS);
  • neurostimulation;
  • Parkinson's disease (PD);
  • subthalamic nucleus (STN)

Summary

The current popularity and widespread acceptance of deep brain stimulation (DBS) for Parkinson's disease (PD) began in the early 1990s after publications from teams in Grenoble and Lille introduced the concept of DBS to ameliorate abnormal movements without destroying tissue. The most common targets for DBS in PD are the ventral intermediate nucleus (Vim), globus pallidus internus (GPi), and subthalamic nucleus (STN). Currently, DBS of the STN is the most common surgical procedure for PD. This chapter highlights this operation and discusses (i) the rationale for neurostimulation of the STN, (ii) referral criteria to select the ideal patient, (iii) outcome, (iv) stimulation parameters, and (v) potential side effects and complications.