5. Deep Brain Stimulation of the Pedunculopontine Nucleus for Parkinson's Disease

  1. Sam Eljamel2 and
  2. Konstantin V. Slavin3
  1. Aviva Abosch and
  2. Amit Goyal

Published Online: 19 JUL 2013

DOI: 10.1002/9781118346396.ch5

Neurostimulation: Principles and Practice

Neurostimulation: Principles and Practice

How to Cite

Abosch, A. and Goyal, A. (2013) Deep Brain Stimulation of the Pedunculopontine Nucleus for Parkinson's Disease, in Neurostimulation: Principles and Practice (eds S. Eljamel and K. V. Slavin), John Wiley & Sons, Ltd, Oxford, UK. doi: 10.1002/9781118346396.ch5

Editor Information

  1. 2

    Centre for Neurosciences, Ninewells Hospital & Medical School, Dundee, Scotland, UK

  2. 3

    Department of Neurosurgery, University of Illinois at Chicago. Chicago, Illinois, USA

Author Information

  1. University of Minnesota, Minneapolis, Minnesota, USA

Publication History

  1. Published Online: 19 JUL 2013
  2. Published Print: 19 AUG 2013

ISBN Information

Print ISBN: 9781118346358

Online ISBN: 9781118346396

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Keywords:

  • deep brain stimulation (DBS);
  • globus pallidus pars interna (GPi);
  • Parkinson's disease (PD);
  • pedunculopontine nucleus (PPN);
  • subthalamic nucleus (STN)

Summary

Parkinson's disease (PD) is the second most common neurodegenerative disorder. Deep brain stimulation (DBS) has become the most widely used surgical intervention for the treatment of PD. The two main targets of DBS for PD are the subthalamic nucleus (STN) and globus pallidus pars interna (GPi), both of which have shown similar efficacy in alleviating parkinsonian motor symptoms. Because of the severe impact that postural instability and gait disturbance have on patients' lives, there has been increased interest in identifying alternate targets for DBS, in an effort to treat these symptoms. The most promising target under investigation is the pedunculopontine nucleus (PPN). As investigations of the PPN as a therapeutic target have moved into clinical studies, results have continued to suggest that the site provides a means to address postural instability and gait dysfunction.