8. Deep Brain Stimulation in Epilepsy

  1. Sam Eljamel2 and
  2. Konstantin V. Slavin3
  1. Michael G. Kaplitt

Published Online: 19 JUL 2013

DOI: 10.1002/9781118346396.ch8

Neurostimulation: Principles and Practice

Neurostimulation: Principles and Practice

How to Cite

Kaplitt, M. G. (2013) Deep Brain Stimulation in Epilepsy, in Neurostimulation: Principles and Practice (eds S. Eljamel and K. V. Slavin), John Wiley & Sons, Ltd, Oxford, UK. doi: 10.1002/9781118346396.ch8

Editor Information

  1. 2

    Centre for Neurosciences, Ninewells Hospital & Medical School, Dundee, Scotland, UK

  2. 3

    Department of Neurosurgery, University of Illinois at Chicago. Chicago, Illinois, USA

Author Information

  1. Weill Cornell Medical College, New York, New York, USA

Publication History

  1. Published Online: 19 JUL 2013
  2. Published Print: 19 AUG 2013

ISBN Information

Print ISBN: 9781118346358

Online ISBN: 9781118346396



  • amygdalahippocampus;
  • anterior nucleus (AN);
  • centromedian nucleus (CM);
  • deep brain stimulation (DBS);
  • epilepsy;
  • subthalamic nucleus (STN);
  • thalamus


Epilepsy has long been considered as a surgical disease for those who do not adequately respond to medication. To directly address the mechanisms whereby seizures establish and spread through the brain without the need for resective surgery, deep brain stimulation (DBS) for epilepsy has gained enthusiasm. An important brain target that has been advanced the farthest in clinical practice is the anterior nucleus (AN) of the thalamus. Others targets include the centromedian nucleus (CM) of the thalamus, the subthalamic nucleus (STN), and the amygdalahippocampus. The overall goal of DBS in epilepsy is to provide a tonic modulation that will act essentially as a sentinel to either prevent abnormal firing from an epileptic focus or prevent spread and generalization of a seizure, and thereby improving quality of life. This chapter provides a detailed rationale for the use of each target and some details of key surgical methodological points.