14. Depression and Alzheimer's Disease

  1. Andres M. Kanner MD5,6,7
  1. Pablo Richly MD1,
  2. Facundo Manes MD2,3,4 and
  3. Julián Bustin MD, MRCPsych1

Published Online: 4 JUL 2012

DOI: 10.1002/9781118348093.ch14

Depression in Neurologic Disorders: Diagnosis and Management

Depression in Neurologic Disorders: Diagnosis and Management

How to Cite

Richly, P., Manes, F. and Bustin, J. (2012) Depression and Alzheimer's Disease, in Depression in Neurologic Disorders: Diagnosis and Management (ed A. M. Kanner), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118348093.ch14

Editor Information

  1. 5

    Departments of Neurological Sciences and Psychiatry, Rush Medical College at Rush University, Chicago, IL, USA

  2. 6

    Laboratory of EEG and Video-EEG-Telemetry, Chicago, IL, USA

  3. 7

    Section of Epilepsy and Rush Epilepsy Center, Rush University Medical Center, Chicago, IL, USA

Author Information

  1. 1

    Institute of Cognitive Neurology (INECO), Buenos Aires, Argentina

  2. 2

    Institute of Neuroscience, Professor of Neurology and Cognitive Neuroscience, Favaloro University, Argentina

  3. 3

    Institute of Cognitive Neurology (INECO), Buenos Aires, Argentina

  4. 4

    World Federation of Neurology, Research Group on Aphasia and Cognitive Disorders, Argentina

Publication History

  1. Published Online: 4 JUL 2012
  2. Published Print: 24 AUG 2012

ISBN Information

Print ISBN: 9781444330588

Online ISBN: 9781118348093



  • depression;
  • dementia;
  • Alzheimer's disease;
  • apathy;
  • dysphoria;
  • antidepressants;
  • nonpharmacological treatments


Alzheimer's disease (AD) is the most prevalent type of dementia. Depression is the most frequent neuropsychiatric syndrome in AD and is associated with greater impairment in activities of daily living, earlier placement in a nursing home, increased mortality risk, faster decline in cognitive functions, and poorer quality of life. Depression also increases stress and psychological morbidity of the patient's caregiver and family. The relationship between depression and AD is complex, and it is likely that they share common pathophysiological pathways. The accurate diagnosis and adequate treatment of depression in patients with AD poses an important clinical conundrum because current diagnostic criteria are unable to detect many patients with depression in AD and there is no clear evidence for the efficacy of pharmacological treatments. In this context, nonpharmacological treatments are extremely relevant.