2. Neurobiological Aspects of Depression: How Do They Affect Neurologic Disorders?

  1. Andres M. Kanner MD2,3,4
  1. Hrvoje Hecimovic MD, PhD

Published Online: 4 JUL 2012

DOI: 10.1002/9781118348093.ch2

Depression in Neurologic Disorders: Diagnosis and Management

Depression in Neurologic Disorders: Diagnosis and Management

How to Cite

Hecimovic, H. (2012) Neurobiological Aspects of Depression: How Do They Affect Neurologic Disorders?, in Depression in Neurologic Disorders: Diagnosis and Management (ed A. M. Kanner), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118348093.ch2

Editor Information

  1. 2

    Departments of Neurological Sciences and Psychiatry, Rush Medical College at Rush University, Chicago, IL, USA

  2. 3

    Laboratory of EEG and Video-EEG-Telemetry, Chicago, IL, USA

  3. 4

    Section of Epilepsy and Rush Epilepsy Center, Rush University Medical Center, Chicago, IL, USA

Author Information

  1. Zagreb Epilepsy Center, Department of Neurology, University Hospital, Zagreb, Croatia

Publication History

  1. Published Online: 4 JUL 2012
  2. Published Print: 24 AUG 2012

ISBN Information

Print ISBN: 9781444330588

Online ISBN: 9781118348093

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Keywords:

  • major depressive disorder;
  • hippocampus;
  • amygdala;
  • limbic system;
  • neurobiology;
  • serotonin;
  • serotonin transporter;
  • norepinephrine;
  • dopamine;
  • cytokine;
  • neuroimmunomodulation;
  • magnetic resonance imaging;
  • positron emission tomography;
  • epilepsy;
  • neurological disorder

Summary

Research on the neurobiology of depression is a unique challenge. Recent studies combining behavioral, molecular, and electrophysiological approaches have shown that certain aspects of depression result from stress-induced neuroplastic changes in specific neural networks. New insights into the neuroinflamatory pathways and genetic variations are developing rapidly. While some disease characteristics have been accurately modeled, other important symptoms such as resilience and suicidality are more difficult to reproduce in current models. Comprehensive investigation of chronic neurological disorders with depression symptoms may further explain possible common neurobiological pathways of both disorders.