8. Basic Principles in the Management of Depression in Neurologic Disorders

  1. Andres M. Kanner MD2,3,4
  1. Marco Mula MD, PhD

Published Online: 4 JUL 2012

DOI: 10.1002/9781118348093.ch8

Depression in Neurologic Disorders: Diagnosis and Management

Depression in Neurologic Disorders: Diagnosis and Management

How to Cite

Mula, M. (2012) Basic Principles in the Management of Depression in Neurologic Disorders, in Depression in Neurologic Disorders: Diagnosis and Management (ed A. M. Kanner), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118348093.ch8

Editor Information

  1. 2

    Departments of Neurological Sciences and Psychiatry, Rush Medical College at Rush University, Chicago, IL, USA

  2. 3

    Laboratory of EEG and Video-EEG-Telemetry, Chicago, IL, USA

  3. 4

    Section of Epilepsy and Rush Epilepsy Center, Rush University Medical Center, Chicago, IL, USA

Author Information

  1. Department of Clinical and Experimental Medicine, Amedeo Avogadro University; Division of Neurology, University Hospital Maggiore della Carità, Novara, Italy

Publication History

  1. Published Online: 4 JUL 2012
  2. Published Print: 24 AUG 2012

ISBN Information

Print ISBN: 9781444330588

Online ISBN: 9781118348093

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Keywords:

  • antidepressant drugs;
  • major depression;
  • side effects;
  • neurologic disorders;
  • epilepsy;
  • headache;
  • Parkinson's disease;
  • multiple sclerosis;
  • epilepsy;
  • Alzheimer's disease

Summary

Major depression represents a frequently encountered psychiatric comorbidity in patients with neurologic disorders. The pharmacological armamentarium for the treatment of depression is rich, with a number of compounds available and a number of drugs in development. However, neurologists are not always at ease with such drug groups due to a lack of education regarding the pharmacology of antidepressants and their relative differences in terms of efficacy and side effects. Moreover, the choice of antidepressant drug must be balanced with the possible deleterious effects on the underlying neurologic condition.

This chapter aims to review basic principles of the clinical pharmacology of antidepressant drugs, with special reference to their use in neurologic patients.