9. Depression and Migraine

  1. Andres M. Kanner MD2,3,4
  1. Joan Roig Llesuy MD

Published Online: 4 JUL 2012

DOI: 10.1002/9781118348093.ch9

Depression in Neurologic Disorders: Diagnosis and Management

Depression in Neurologic Disorders: Diagnosis and Management

How to Cite

Llesuy, J. R. (2012) Depression and Migraine, in Depression in Neurologic Disorders: Diagnosis and Management (ed A. M. Kanner), Wiley-Blackwell, Oxford, UK. doi: 10.1002/9781118348093.ch9

Editor Information

  1. 2

    Departments of Neurological Sciences and Psychiatry, Rush Medical College at Rush University, Chicago, IL, USA

  2. 3

    Laboratory of EEG and Video-EEG-Telemetry, Chicago, IL, USA

  3. 4

    Section of Epilepsy and Rush Epilepsy Center, Rush University Medical Center, Chicago, IL, USA

Author Information

  1. Neuropsychiatry and Addiction Institute, Hospital del Mar, Barcelona, Spain

Publication History

  1. Published Online: 4 JUL 2012
  2. Published Print: 24 AUG 2012

ISBN Information

Print ISBN: 9781444330588

Online ISBN: 9781118348093



  • suicide;
  • major depressive disorder;
  • bipolar disorder;
  • migraine with aura


Migraine and depression are common disorders that have significant negative repercussions on patients' lives. Epidemiologic studies have demonstrated comorbidity between psychiatric disorders, particularly mood disorders and migraine, which may worsen the prognosis. This high comorbidity is most likely related to the existence of common pathogenic mechanisms operant in these conditions. This chapter reviews the close relation between mood disorders and migraine and the clinical manifestations of depressive episodes in patients with these conditions, especially their increased suicidal risk. The utility and limitations of screening instruments and treatment strategies of depressive disorders in patients with migraines will also be reviewed.