16. Epigenetic Biomarkers in Cancer Detection and Diagnosis

  1. Saura C. Sahu
  1. Ashley G. Rivenbark1 and
  2. William B. Coleman2

Published Online: 8 AUG 2012

DOI: 10.1002/9781118349045.ch16

Toxicology and Epigenetics

Toxicology and Epigenetics

How to Cite

Rivenbark, A. G. and Coleman, W. B. (2012) Epigenetic Biomarkers in Cancer Detection and Diagnosis, in Toxicology and Epigenetics (ed S. C. Sahu), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781118349045.ch16

Editor Information

  1. Division of Toxicology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, Maryland, USA

Author Information

  1. 1

    Department of Pathology and Laboratory Medicine, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA

  2. 2

    Department of Pathology and Laboratory Medicine, Curriculum in Toxicology, Program in Translational Medicine, UNC Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC, USA

Publication History

  1. Published Online: 8 AUG 2012
  2. Published Print: 7 SEP 2012

ISBN Information

Print ISBN: 9781119976097

Online ISBN: 9781118349045

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Keywords:

  • epigenetic biomarkers in cancer detection/diagnosis;
  • DNA methylation, hallmark of epigenetic modifications;
  • DNA methylation on cytosines, within CpG dinucleotides;
  • DNMTs, catalyzing addition of methyl groups onto cytosine;
  • DNA methylation-mediated regulation of transcription;
  • cancer epigenetics, governing uncontrolled cellular proliferation;
  • diagnostic tests and epigenetic biomarkers, determining cancer risk;
  • DNA methylation and gene silencing in cancer;
  • genes commonly methylated in multiple human cancers;
  • DNA methylation of epigenetic, and molecular assays

Summary

This chapter contains sections titled:

  • DNA methylation

  • Epigenetics of cancer

  • Epigenetic biomarkers for cancer diagnostics: DNA methylation

  • Application of aberrant DNA methylation to cancer diagnostics

  • Epigenetic biomarkers in breast cancer

  • Epigenetic biomarkers in prostate cancer

  • Epigenetic biomarkers in lung cancer

  • Epigenetic biomarkers in colorectal cancer

  • Epigenetic biomarkers in liver cancer

  • Cancer detection and diagnosis

  • References