17. Epigenetic Histone Changes in the Toxicologic Mode of Action of Arsenic

  1. Saura C. Sahu
  1. John F. Reichard and
  2. Alvaro Puga

Published Online: 8 AUG 2012

DOI: 10.1002/9781118349045.ch17

Toxicology and Epigenetics

Toxicology and Epigenetics

How to Cite

Reichard, J. F. and Puga, A. (2012) Epigenetic Histone Changes in the Toxicologic Mode of Action of Arsenic, in Toxicology and Epigenetics (ed S. C. Sahu), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781118349045.ch17

Editor Information

  1. Division of Toxicology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, Maryland, USA

Author Information

  1. Department of Environmental Health and Center for Environmental Genetics, University of Cincinnati College of Medicine, Cincinnati, OH, USA

Publication History

  1. Published Online: 8 AUG 2012
  2. Published Print: 7 SEP 2012

ISBN Information

Print ISBN: 9781119976097

Online ISBN: 9781118349045



  • epigenetic histone changes in toxicologic MoA;
  • epidemiologic evidence, inorganic As to human cancers;
  • precise carcinogenic MoA for arsenic, unknown;
  • arsenic as acting through multiple indirect, and cancer risk;
  • DNA hypermethylation, in tumor suppressor gene silencing;
  • As in multiple/epigenetic dysregulation, and genetic instability;
  • As on DNA methylation, areas of research interest;
  • H4K16 acetylation, in BRD4, gene induction and H3S10 in As;
  • As's toxicologic MoA, and histone epigenetic marks


This chapter contains sections titled:

  • Introduction

  • Epigenetics and cancer

  • Epigenetics effects of arsenic

  • Conclusions

  • References