2. Environment, Epigenetics, and Diseases

  1. Saura C. Sahu
  1. Robert Y. S. Cheng1 and
  2. Wan-yee Tang2

Published Online: 8 AUG 2012

DOI: 10.1002/9781118349045.ch2

Toxicology and Epigenetics

Toxicology and Epigenetics

How to Cite

Cheng, R. Y. S. and Tang, W.-y. (2012) Environment, Epigenetics, and Diseases, in Toxicology and Epigenetics (ed S. C. Sahu), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781118349045.ch2

Editor Information

  1. Division of Toxicology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, Maryland, USA

Author Information

  1. 1

    Radiation Biology Branch, Center for Cancer Research, National Cancer Institute, Bethesda, MD, USA

  2. 2

    Division of Molecular and Translational Toxicology, Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA

Publication History

  1. Published Online: 8 AUG 2012
  2. Published Print: 7 SEP 2012

ISBN Information

Print ISBN: 9781119976097

Online ISBN: 9781118349045



  • environment, epigenetics, diseases, and critical window of exposure;
  • disease susceptibility, genetic make-up and epigenetic modulations;
  • gene expression epigenetic disruption, and genetic predisposition;
  • DNA methylation enzymes and complex histone modifications;
  • histone/chromatin remodeling during DNA replication, elusive;
  • TCDD, by-products of fossil fuels/wood incomplete combustion;
  • dietary factors, micronutrients/and polyphenols, modifying epigenetic marks;
  • epigenetic marks, new generation of biomarkers in disease diagnosis


This chapter contains sections titled:

  • Perceptions of epigenetics

  • Environmental epigenetics and human diseases

  • Implications of environmental epigenetics and future prospects

  • Key questions to be answered

  • Acknowledgments

  • References