24. Carcinogenic Metals Alter Histone Tail Modifications

  1. Saura C. Sahu
  1. Yana Chervona and
  2. Max Costa

Published Online: 8 AUG 2012

DOI: 10.1002/9781118349045.ch24

Toxicology and Epigenetics

Toxicology and Epigenetics

How to Cite

Chervona, Y. and Costa, M. (2012) Carcinogenic Metals Alter Histone Tail Modifications, in Toxicology and Epigenetics (ed S. C. Sahu), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781118349045.ch24

Editor Information

  1. Division of Toxicology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, Maryland, USA

Author Information

  1. Department of Environmental Medicine, NYU School of Medicine, Tuxedo, NY, USA

Publication History

  1. Published Online: 8 AUG 2012
  2. Published Print: 7 SEP 2012

ISBN Information

Print ISBN: 9781119976097

Online ISBN: 9781118349045



  • carcinogenic metals, in altering histone tail modifications;
  • epigenetics and histone tail modifications;
  • DNA methylation, or epigenetic alterations;
  • histone addition/removal, and histone modifying enzymes;
  • As as double edged sword, carcinogenic/therapeutic;
  • histone phosphorylation, role in arsenic-induced carcinogenesis;
  • nickel/chromium/cadmium on post-translational modification;
  • metal-induced gene specific/histone mark signatures, as biomarkers


This chapter contains sections titled:

  • Introduction

  • Epigenetics and histone tail modifications

  • Arsenic

  • Nickel

  • Hexavalent chromium (Cr [VI])

  • Cadmium

  • Summary

  • References