25. Prediction of Epigenetic and Stochastic Gene Expression Profiles of Late Effects after Radiation Exposure

  1. Saura C. Sahu
  1. Yoko Hirabayashi1 and
  2. Tohru Inoue2

Published Online: 8 AUG 2012

DOI: 10.1002/9781118349045.ch25

Toxicology and Epigenetics

Toxicology and Epigenetics

How to Cite

Hirabayashi, Y. and Inoue, T. (2012) Prediction of Epigenetic and Stochastic Gene Expression Profiles of Late Effects after Radiation Exposure, in Toxicology and Epigenetics (ed S. C. Sahu), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781118349045.ch25

Editor Information

  1. Division of Toxicology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, Maryland, USA

Author Information

  1. 1

    Division of Cellular and Molecular Toxicology, National Center for Biological Safety and Research, National Institute of Health Sciences, Setagaya, Tokyo, Japan

  2. 2

    Department of Biological Function and Structural Medicine, Nihon University School of Medicine, Itabashi, Tokyo, Japan

Publication History

  1. Published Online: 8 AUG 2012
  2. Published Print: 7 SEP 2012

ISBN Information

Print ISBN: 9781119976097

Online ISBN: 9781118349045

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Keywords:

  • epigenetic/stochastic gene profiles of radiation exposure;
  • gene chip/microarray, toxicological, toxicity/carcinogenicity bioassay;
  • toxicoepigenomics, probabilistic/stochastic use of gene chip/microarray;
  • probabilistic/stochastic profiles, analytical technological development;
  • radiation exposure and dosimetric quantum biology;
  • ionizing-radiation-induced biological effects, CLEGs instead of CEGs;
  • stochastic expression gene profiles after radiation, and SEGs in radiation

Summary

This chapter contains sections titled:

  • Introduction – pathological profiling (diagnostic endpoint) and toxicological profiling (probabilistic endpoint)

  • Radiation exposure and dosimetric quantum biology

  • Common gene expression profiles after subacute and prolonged effects after radiation exposure

  • Stochastic expression gene profiles after radiation exposure

  • Conclusions

  • Appendix A

  • Appendix B

  • Appendix C

  • References