27. Chromatin Insulators and Epigenetic Inheritance in Health and Disease

  1. Saura C. Sahu
  1. Jingping Yang and
  2. Victor G. Corces

Published Online: 8 AUG 2012

DOI: 10.1002/9781118349045.ch27

Toxicology and Epigenetics

Toxicology and Epigenetics

How to Cite

Yang, J. and Corces, V. G. (2012) Chromatin Insulators and Epigenetic Inheritance in Health and Disease, in Toxicology and Epigenetics (ed S. C. Sahu), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781118349045.ch27

Editor Information

  1. Division of Toxicology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, Maryland, USA

Author Information

  1. Department of Biology, Emory University, Atlanta, Georgia, USA

Publication History

  1. Published Online: 8 AUG 2012
  2. Published Print: 7 SEP 2012

ISBN Information

Print ISBN: 9781119976097

Online ISBN: 9781118349045



  • chromatin insulators, epigenetic inheritance in health and disease;
  • specific gene expression/repression, alterations in local chromatin;
  • chromatin insulators, DNA-bound, intra-/inter-chromosome interactions;
  • insulators, in establishment/maintenance of 3D of genome;
  • insulators, as DNA–protein, blocking promoter interactions;
  • CTCF, context-dependent with different protein partners;
  • insulator activity, RNAi machinery regulated;
  • insulator role in chromosomal, regulating enhancer function;
  • insulators, targets manipulating epigenetic status of cells


This chapter contains sections titled:

  • Introduction

  • Structure and organization of insulators

  • Insulators and chromatin architecture

  • Regulation of insulator function

  • Insulators and the external/internal cellular environment

  • Insulators and disease

  • Concluding remarks

  • Acknowledgments

  • References