32. Epigenetic Modifications in Chemical Carcinogenesis

  1. Saura C. Sahu
  1. Igor P. Pogribny,
  2. Igor Koturbash and
  3. Frederick A. Beland

Published Online: 8 AUG 2012

DOI: 10.1002/9781118349045.ch32

Toxicology and Epigenetics

Toxicology and Epigenetics

How to Cite

Pogribny, I. P., Koturbash, I. and Beland, F. A. (2012) Epigenetic Modifications in Chemical Carcinogenesis, in Toxicology and Epigenetics (ed S. C. Sahu), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781118349045.ch32

Editor Information

  1. Division of Toxicology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, Maryland, USA

Author Information

  1. Division of Biochemical Toxicology, National Center for Toxicological Research, Jefferson, AR, USA

  1. The views expressed in this paper do not necessarily represent those of the U.S. Food and Drug Administration.

Publication History

  1. Published Online: 8 AUG 2012
  2. Published Print: 7 SEP 2012

ISBN Information

Print ISBN: 9781119976097

Online ISBN: 9781118349045



  • epigenetic modifications in chemical carcinogenesis;
  • cancer-specific phenotypes, genome mutational/non-mutational changes;
  • ‘Epigenetics,’ stable/heritable changes, not DNA sequence changes;
  • epigenetic alterations in cancer cells;
  • demethylation of repetitive elements, oncogenes, and imprinted genes;
  • DNA methylation loss as causes/consequences of carcinogenic, unclear;
  • pattern disruption of covalent histone, epigenetic abnormality;
  • nickel/chromium/cadmium/mercury exposure, and epigenetic alterations


This chapter contains sections titled:

  • Introduction

  • Epigenetic alterations in cancer cells

  • Role of epigenetic alterations in chemical carcinogenesis

  • Future perspectives: epigenetic alterations and cancer risk assessment

  • References