4. Chromatin at the Intersection of Disease and Therapy

  1. Saura C. Sahu
  1. Delphine Quénet,
  2. Marcin Walkiewicz and
  3. Yamini Dalal

Published Online: 8 AUG 2012

DOI: 10.1002/9781118349045.ch4

Toxicology and Epigenetics

Toxicology and Epigenetics

How to Cite

Quénet, D., Walkiewicz, M. and Dalal, Y. (2012) Chromatin at the Intersection of Disease and Therapy, in Toxicology and Epigenetics (ed S. C. Sahu), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781118349045.ch4

Editor Information

  1. Division of Toxicology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, Maryland, USA

Author Information

  1. Laboratory of Receptor Biology & Gene Expression, National Cancer Institute, Bethesda, MD, USA

Publication History

  1. Published Online: 8 AUG 2012
  2. Published Print: 7 SEP 2012

ISBN Information

Print ISBN: 9781119976097

Online ISBN: 9781118349045



  • chromatin at the intersection of disease and therapy;
  • epigenetic marks on chromatin, a complex pathway;
  • chromatin dynamics/compaction, by DNA methylation, PTMs of histones;
  • DNA methylation/histone modifications, regulating chromatin state;
  • altered patterns of DNA methylation and PTMs of histones, as in cancer;
  • metabolic memory, cause of epigenetic modifications and diabetes;
  • epigenetic alteration in neurodegenerative disorders;
  • HDAC, CREB-dependent and acetylation, in memory/synaptic plasticity


This chapter contains sections titled:

  • Epigenetic marks on chromatin: a complex pathway with high flexibility

  • Epigenetic approaches to treatment of cancer

  • Epigenetic modifications and potential therapy in other diseases

  • Conclusion

  • References