7. Epigenomic Actions of Environmental Arsenicals

  1. Saura C. Sahu
  1. Paul L. Severson1,2 and
  2. Bernard W. Futscher2

Published Online: 8 AUG 2012

DOI: 10.1002/9781118349045.ch7

Toxicology and Epigenetics

Toxicology and Epigenetics

How to Cite

Severson, P. L. and Futscher, B. W. (2012) Epigenomic Actions of Environmental Arsenicals, in Toxicology and Epigenetics (ed S. C. Sahu), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781118349045.ch7

Editor Information

  1. Division of Toxicology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, Maryland, USA

Author Information

  1. 1

    Department of Pharmacology and Toxicology, College of Pharmacy and The University of Arizona Cancer Center, The University of Arizona, Tucson, AR, USA

  2. 2

    Department of Pharmacology & Toxicology, College of Pharmacy and The University of Arizona Cancer Center, The University of Arizona, Tucson, AZ, USA

Publication History

  1. Published Online: 8 AUG 2012
  2. Published Print: 7 SEP 2012

ISBN Information

Print ISBN: 9781119976097

Online ISBN: 9781118349045

SEARCH

Keywords:

  • epigenomic actions of environmental arsenicals;
  • arsenic, ‘Poison of Kings and King of Poisons’;
  • environmental arsenic and plethora of human toxicities;
  • long-term arsenic exposure, cancer, in human mortality;
  • multiple mechanisms of arsenical toxicity, additive/synergistic;
  • cellular ROS increase, following arsenic exposure;
  • human cell lines, determining arsenical induced toxicity;
  • SAM methyl-donor for DNA methylation/arsenic methylation

Summary

This chapter contains sections titled:

  • Introduction

  • Arsenicals in relation to human health

  • Arsenical mechanisms of action

  • Models to study arsenical action

  • Models used to study epigenetic action

  • Epigenetic effects of arsenicals

  • Perspectives

  • References