8. Arsenic-Induced Changes to the Epigenome

  1. Saura C. Sahu
  1. Kathryn A. Bailey1 and
  2. Rebecca C. Fry1,2

Published Online: 8 AUG 2012

DOI: 10.1002/9781118349045.ch8

Toxicology and Epigenetics

Toxicology and Epigenetics

How to Cite

Bailey, K. A. and Fry, R. C. (2012) Arsenic-Induced Changes to the Epigenome, in Toxicology and Epigenetics (ed S. C. Sahu), John Wiley & Sons, Ltd, Chichester, UK. doi: 10.1002/9781118349045.ch8

Editor Information

  1. Division of Toxicology, Center for Food Safety and Applied Nutrition, Food and Drug Administration, Laurel, Maryland, USA

Author Information

  1. 1

    Environmental Sciences and Engineering, The University of North Carolina Gillings School of Global Public Health, UNC-Chapel Hill, Chapel Hill, NC, USA

  2. 2

    Department of Environmental Sciences and Engineering, Gillings School of Global Public Health, The University of North Carolina-Chapel Hill, NC, USA

Publication History

  1. Published Online: 8 AUG 2012
  2. Published Print: 7 SEP 2012

ISBN Information

Print ISBN: 9781119976097

Online ISBN: 9781118349045



  • arsenic-induced changes to the epigenome;
  • chronic As poisoning, significant worldwide health concern;
  • precise mechanisms of As-mediated disease, elusive;
  • epigenetic alterations, role in human disease development;
  • epigenetic modifications, determining phenotypic variation;
  • gene silencing by CpG methylation, and mechanisms;
  • DNA methylation patterns and active DNA methylation/demethylation;
  • arsenic exposure effects, and metabolism on cofactor availability;
  • alterations in DNA methylation with As exposure in utero;
  • histone modifications, and arsenic exposure


This chapter contains sections titled:

  • Introduction

  • Arsenic exposure and DNA methylation

  • DNA methylation changes associated with arsenic exposure

  • Histone modifications associated with arsenic exposure

  • MicroRNA (miRNA) alterations associated with arsenic exposure

  • Conclusions and future directions

  • Acknowledgments

  • References