2. Bone–Tendon–Ligament System

  1. Zaher A. Radi

Published Online: 20 AUG 2012

DOI: 10.1002/9781118351918.ch2

Comparative Pathophysiology and Toxicology of Cyclooxygenases

Comparative Pathophysiology and Toxicology of Cyclooxygenases

How to Cite

Radi, Z. A. (2012) Bone–Tendon–Ligament System, in Comparative Pathophysiology and Toxicology of Cyclooxygenases, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118351918.ch2

Author Information

  1. Pfizer Worldwide Research and Development Drug Safety Research and Development Cambridge, Massachusetts, USA

Publication History

  1. Published Online: 20 AUG 2012
  2. Published Print: 24 AUG 2012

ISBN Information

Print ISBN: 9780470577547

Online ISBN: 9781118351918

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Keywords:

  • bone–tendon–ligament, PG on skeleton and NSAID on bone;
  • PGs and bone healing, in repair process;
  • mesenchymal cells, role in endochondral bone ossification;
  • effects of ns-NSAIDs on bone healing;
  • effects of ns-NSAIDs on ligament and tendon healing

Summary

This chapter contains sections titled:

  • Introduction

  • Comparative Physiological and Anatomical Aspects of the Skeleton

  • Role of Prostaglandins in Skeleton Metabolism

  • The Process of Bone Healing and Potential Role of Prostaglandins

  • COX-1 and COX-2 Expression in Bone, Tendon, and Ligament During Repair and in Pathological Conditions

  • Effects of ns-NSAIDs on Bone Healing

  • Effects of COX-2 s-NSAIDs on Bone Healing

  • Effects of ns-NSAIDs on Ligament and Tendon Healing

  • Effects of COX-2 s-NSAIDs on Ligament and Tendon Healing

  • Conclusions

  • References