13. Biopharmaceutical Modeling for Miscellaneous Cases

  1. Kiyohiko Sugano

Published Online: 8 AUG 2012

DOI: 10.1002/9781118354339.ch13

Biopharmaceutics Modeling and Simulations: Theory, Practice, Methods, and Applications

Biopharmaceutics Modeling and Simulations: Theory, Practice, Methods, and Applications

How to Cite

Sugano, K. (2012) Biopharmaceutical Modeling for Miscellaneous Cases, in Biopharmaceutics Modeling and Simulations: Theory, Practice, Methods, and Applications, John Wiley & Sons, Inc., Hoboken, NJ, USA. doi: 10.1002/9781118354339.ch13

Author Information

  1. Asahi Kasei Pharma Corp., Shizuoka, Japan

Publication History

  1. Published Online: 8 AUG 2012
  2. Published Print: 20 AUG 2012

ISBN Information

Print ISBN: 9781118028681

Online ISBN: 9781118354339

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Keywords:

  • free acids and undissociable drugs;
  • intestinal first-pass metabolism;
  • transit time effect, gastric emptying time;
  • intestinal transit time;
  • other chemical and physical drug–drug interactions

Summary

This chapter contains sections titled:

  • Stomach pH Effect on Solubility and Dissolution Rate

  • Intestinal First-Pass Metabolism

  • Transit Time Effect

  • Other Chemical and Physical Drug–Drug Interactions

  • Species Difference

  • Validation of GI Site-Specific Absorption Models

  • References