2. Hydrogenation of Esters

  1. Peter J. Dunn2,
  2. K. K. (Mimi) Hii3,
  3. Michael J. Krische4 and
  4. Michael T. Williams5
  1. Lionel A. Saudan

Published Online: 23 MAY 2013

DOI: 10.1002/9781118354520.ch02

Sustainable Catalysis: Challenges and Practices for the Pharmaceutical and Fine Chemical Industries

Sustainable Catalysis: Challenges and Practices for the Pharmaceutical and Fine Chemical Industries

How to Cite

Saudan, L. A. (2013) Hydrogenation of Esters, in Sustainable Catalysis: Challenges and Practices for the Pharmaceutical and Fine Chemical Industries (eds P. J. Dunn, K. K. (. Hii, M. J. Krische and M. T. Williams), John Wiley & Sons, Inc., Hoboken, New Jersey. doi: 10.1002/9781118354520.ch02

Editor Information

  1. 2

    Pfizer Green Chemistry Lead, Sandwich, Kent, United Kingdom

  2. 3

    Imperial College London, South Kensington, London, United Kingdom

  3. 4

    University of Texas at Austin, Austin, Texas, United States of America

  4. 5

    CMC Consultant, Deal, Kent, United Kingdom

Author Information

  1. Corporate R&D Division, Firmenich SA, Geneva, Switzerland

Publication History

  1. Published Online: 23 MAY 2013
  2. Published Print: 8 APR 2013

ISBN Information

Print ISBN: 9781118155424

Online ISBN: 9781118354520

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Keywords:

  • agrochemical industry;
  • aliphatic esters;
  • aromatic esters;
  • catalytic hydrogenation;
  • chiral esters;
  • furanoic esters;
  • lactones; pharmaceutical industry

Summary

Catalytic hydrogenation of esters is a very attractive methodology to replace the use of hazardous hydride reagents based on aluminum, silicon, and boron, for the reduction of esters on a large scale. This chapter describes a survey of newly developed homogeneous catalysts. It is divided by substrate classes, with a discussion on the catalyst choice and efficiency for each class of substrate studied. Some examples of application of the target alcohols or diols are also given. The substrate scope for the hydrogenation of esters with ruthenium catalysts has been focused merely on simple aliphatic and aromatic esters; for a future industrial implementation of these catalysts, the scope of esters has to be widened to more complex substrates used in the pharmaceutical and agrochemical industries.